G
Gene B. Hubbard
Researcher at Murphy Oil
Publications - 8
Citations - 1778
Gene B. Hubbard is an academic researcher from Murphy Oil. The author has contributed to research in topics: Offspring & Cannabinoid receptor. The author has an hindex of 4, co-authored 8 publications receiving 1269 citations. Previous affiliations of Gene B. Hubbard include University of Texas Health Science Center at San Antonio & University of Texas at San Antonio.
Papers
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Rapamycin extends life and health in C57BL/6 mice.
Yiqiang Zhang,Alex Bokov,Jonathan Gelfond,Vanessa Y. Soto,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Vivian Diaz,Lauren B. Sloane,Keith Maslin,Stephen Treaster,Samantha Rendon,Holly Van Remmen,Walter F. Ward,Martin A. Javors,Arlan Richardson,Steven N. Austad,Kathleen E. Fischer +17 more
TL;DR: Rapamycin feeding significantly reduced mTOR activity in most but not all tissues and reduced total and resting metabolic rate during the light:dark cycle in females only but had no effect on spontaneous activity or metabolism during the dark phase of either sex.
Journal ArticleDOI
IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan
Nicole M. Ashpole,Sreemathi Logan,Andriy Yabluchanskiy,Matthew Mitschelen,Han Yan,Julie A. Farley,Erik L. Hodges,Zoltan Ungvari,Anna Csiszar,Sixia Chen,Constantin Georgescu,Gene B. Hubbard,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,William E. Sonntag +15 more
TL;DR: The results support the concept that IGF-1 levels early during lifespan establish the conditions necessary for subsequent healthspan and pathological changes that contribute to aging, and these changes are specific for each sex and tissue.
Book ChapterDOI
Fetal Origins of Obesity and Diabetes
TL;DR: Although it remains unknown whether alteration of the intrauterine environment can reduce the lifelong risks of developing obesity and/or T2DM, maternal health during gestation impacts the lifelong health of the offspring.
Journal ArticleDOI
The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology.
Iram P. Rodriguez-Sanchez,Josée Guindon,Marco Ruiz,M. Elizabeth Tejero,Gene B. Hubbard,Laura Elia Martínez-de-Villarreal,Hugo A. Barrera-Saldaña,Edward J. Dick,Anthony G. Comuzzie,Natalia Schlabritz-Loutsevitch +9 more
TL;DR: Evaluation of the data, obtained in non-human primate model of cannabis-related developmental exposure should take into consideration possible evolutionary-determined species-specific differences in the CB1R expression, CB2R transduction pathway, and FAAH and DAGLα substrate-enzyme interactions.