N
Nino Giorgadze
Researcher at Mayo Clinic
Publications - 34
Citations - 8147
Nino Giorgadze is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Adipose tissue & Adipogenesis. The author has an hindex of 22, co-authored 28 publications receiving 5694 citations. Previous affiliations of Nino Giorgadze include Boston University.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors.
Yi Zhu,Tamara Tchkonia,Heike Fuhrmann-Stroissnigg,Haiming Dai,Yuanyuan Y. Ling,Michael B. Stout,Tamar Pirtskhalava,Nino Giorgadze,Kurt O. Johnson,Cory B. Giles,Jonathan D. Wren,Laura J. Niedernhofer,Paul D. Robbins,James L. Kirkland +13 more
TL;DR: The hypothesis‐driven, bioinformatics‐based approach used to discover that dasatinib (D) and quercetin (Q) are senolytic can be extended to increase the repertoire ofsenolytic drugs, including additional cell type‐specific senolytics agents.
Journal ArticleDOI
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.
La Tonya J. Hickson,Larissa G.P. Langhi Prata,Shane A. Bobart,Tamara K. Evans,Nino Giorgadze,Shahrukh K. Hashmi,Sandra M. Herrmann,Michael D. Jensen,Qingyi Jia,Kyra L. Jordan,Todd A. Kellogg,Sundeep Khosla,Daniel M. Koerber,Anthony B. Lagnado,Donna K. Lawson,Nathan K. LeBrasseur,Lilach O. Lerman,Kathleen M. McDonald,Travis J. McKenzie,João F. Passos,Robert J. Pignolo,Tamar Pirtskhalava,Ishran M. Saadiq,Kalli K. Schaefer,Stephen C. Textor,Stella Victorelli,Tammie L Volkman,Ailing Xue,Mark A. Wentworth,Erin O. Wissler Gerdes,Yi Zhu,Tamara Tchkonia,James L. Kirkland +32 more
TL;DR: “Hit-and-run” treatment with senolytics, which in the case of D’+ Q have elimination half-lives <11 h, significantly decreases senescent cell burden in humans.
Journal ArticleDOI
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu,Tamara Tchkonia,Husheng Ding,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Ellen R. Lubbers,Tamar Pirtskhalava,Thomas A. White,Kurt O. Johnson,Michael B. Stout,Vojtech Mezera,Nino Giorgadze,Michael D. Jensen,Nathan K. LeBrasseur,James L. Kirkland +14 more
TL;DR: It is found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory cytokines compared with nonsenescent cells.