scispace - formally typeset
N

Nicholas F. LaRusso

Researcher at Mayo Clinic

Publications -  429
Citations -  34879

Nicholas F. LaRusso is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Primary sclerosing cholangitis & Cholangiocyte. The author has an hindex of 102, co-authored 418 publications receiving 30974 citations. Previous affiliations of Nicholas F. LaRusso include University of Michigan & Western Infirmary.

Papers
More filters
Journal ArticleDOI

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi-Yi Zhu, +34 more
- 01 Aug 2015 - 
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Biliary tract cancers

Piet C. de Groen, +4 more
- 28 Oct 1999 - 
TL;DR: In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually as mentioned in this paper, which is the second most common primary hepatobiliary cancer after hepatocellular cancer.
Journal ArticleDOI

Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis

Russell H. Wiesner, +9 more
- 01 Oct 1989 - 
TL;DR: Multivariate analysis (Cox proportional hazards regression modeling) revealed that age, serum bilirubin concentration, blood hemoglobin concentration, presence or absence of inflammatory bowel disease and histologic stage on liver biopsy were independent predictors of high risk of dying.
Journal Article

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism.

Meeta Jaiswal, +3 more
- 01 Jan 2000 - 
TL;DR: The data indicate that activation of iNOS and excess production of NO in response to inflammatory cytokines cause DNA damage and inhibit DNA repair proteins and NO inactivation of DNA repair enzymes may provide a link between inflammation and the initiation, promotion, and/or progression of cholangiocarcinoma.