J
Joshua N. Farr
Researcher at Mayo Clinic
Publications - 86
Citations - 7294
Joshua N. Farr is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Senescence & Osteoporosis. The author has an hindex of 31, co-authored 72 publications receiving 4862 citations. Previous affiliations of Joshua N. Farr include University of Rochester & University of Missouri–Kansas City.
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Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
Senolytics improve physical function and increase lifespan in old age
Ming Xu,Ming Xu,Tamar Pirtskhalava,Joshua N. Farr,Bettina M. Weigand,Bettina M. Weigand,Allyson K. Palmer,Megan M. Weivoda,Christina L. Inman,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Christine M Hachfeld,Daniel G. Fraser,Jennifer L Onken,Kurt O. Johnson,Grace C Verzosa,Larissa G.P. Langhi,Moritz Weigl,Nino Giorgadze,Nathan K. LeBrasseur,Jordan D. Miller,Diana Jurk,Ravinder J. Singh,David B. Allison,David B. Allison,Keisuke Ejima,Keisuke Ejima,Gene B. Hubbard,Yuji Ikeno,Yuji Ikeno,Hajrunisa Cubro,Vesna D. Garovic,Xiaonan Hou,S. John Weroha,Paul D. Robbins,Laura J. Niedernhofer,Sundeep Khosla,Tamara Tchkonia,James L. Kirkland +38 more
TL;DR: It is demonstrated that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice.
Journal ArticleDOI
Targeting cellular senescence prevents age-related bone loss in mice
Joshua N. Farr,Ming Xu,Megan M. Weivoda,David G. Monroe,Daniel G. Fraser,Jennifer L Onken,Brittany A Negley,Jad G Sfeir,Mikolaj Ogrodnik,Christine M Hachfeld,Nathan K. LeBrasseur,Matthew T. Drake,Robert J. Pignolo,Tamar Pirtskhalava,Tamara Tchkonia,Merry Jo Oursler,James L. Kirkland,Sundeep Khosla +17 more
TL;DR: A causal role for senescent cells in bone loss with aging is established, and targeting these cells has both anti-resorptive and anabolic effects on bone, which suggests a novel treatment strategy not only for osteoporosis, but also for multiple age-related comorbidities.
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In vivo assessment of bone quality in postmenopausal women with type 2 diabetes.
Joshua N. Farr,Matthew M Drake,Shreyasee Amin,L. Joseph Melton,Louise K. McCready,Sundeep Khosla +5 more
TL;DR: In vivo microindentation testing of the tibia is performed to directly measure bone microarchitecture in 60 postmenopausal women to represent the first demonstration of compromised BMS in patients with T2D and highlight the potential detrimental effects of prolonged hyperglycemia on bone quality.
Journal ArticleDOI
Identification of Senescent Cells in the Bone Microenvironment
Joshua N. Farr,Daniel G. Fraser,Haitao Wang,Katharina Jaehn,Mikolaj Ogrodnik,Megan M. Weivoda,Matthew T. Drake,Tamara Tchkonia,Nathan K. LeBrasseur,James L. Kirkland,Lynda F. Bonewald,Robert J. Pignolo,David G. Monroe,Sundeep Khosla +13 more
TL;DR: Data show that with aging, a subset of cells of various lineages within the bone microenvironment become senescent, although senescent myeloid cells and senescent osteocytes predominantly develop the senescence‐associated secretory phenotype.