H
Husheng Ding
Researcher at Mayo Clinic
Publications - 30
Citations - 3225
Husheng Ding is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Gene & Tipifarnib. The author has an hindex of 17, co-authored 28 publications receiving 2388 citations. Previous affiliations of Husheng Ding include University of Science and Technology of China.
Papers
More filters
Journal ArticleDOI
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Yi-Yi Zhu,Tamara Tchkonia,Tamar Pirtskhalava,Adam C. Gower,Husheng Ding,Nino Giorgadze,Allyson K. Palmer,Yuji Ikeno,Yuji Ikeno,Gene B. Hubbard,Gene B. Hubbard,Marc E. Lenburg,Steven P. O'Hara,Nicholas F. LaRusso,Jordan D. Miller,Carolyn M Roos,Grace C Verzosa,Nathan K. LeBrasseur,Jonathan D. Wren,Joshua N. Farr,Sundeep Khosla,Michael B. Stout,Sara J. McGowan,Heike Fuhrmann-Stroissnigg,Aditi U. Gurkar,Jing-jing Zhao,Debora Colangelo,Akaitz Dorronsoro,Yuan Yuan Ling,Amira S. Barghouthy,Diana C. Navarro,Tokio Sano,Paul D. Robbins,Laura J. Niedernhofer,James L. Kirkland +34 more
TL;DR: The results demonstrate the feasibility of selectively ablating senescent cells and the efficacy of senolytics for alleviating symptoms of frailty and extending healthspan.
Journal ArticleDOI
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu,Tamara Tchkonia,Husheng Ding,Mikolaj Ogrodnik,Mikolaj Ogrodnik,Ellen R. Lubbers,Tamar Pirtskhalava,Thomas A. White,Kurt O. Johnson,Michael B. Stout,Vojtech Mezera,Nino Giorgadze,Michael D. Jensen,Nathan K. LeBrasseur,James L. Kirkland +14 more
TL;DR: It is found that senescent fat progenitor cells accumulate in adipose tissue with aging and acquire a senescence-associated secretory phenotype (SASP), with increased production of proinflammatory cytokines compared with nonsenescent cells.
Journal ArticleDOI
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Ming Xu,Allyson K. Palmer,Husheng Ding,Megan M. Weivoda,Tamar Pirtskhalava,Thomas A. White,Anna Sepe,Kurt O. Johnson,Michael B. Stout,Nino Giorgadze,Michael D. Jensen,Nathan K. LeBrasseur,Tamar Tchkonia,James L. Kirkland +13 more
TL;DR: This study indicates targeting senescent cells or their products may alleviate age-related dysfunction of progenitors, adipose tissue, and metabolism.
Journal ArticleDOI
Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.
Cristina Correia,Sun Hee Lee,X. Wei Meng,Nicole D. Vincelette,Katherine L.B. Knorr,Husheng Ding,Grzegorz S. Nowakowski,Haiming Dai,Scott H. Kaufmann +8 more
TL;DR: Recent advances in understanding Bcl-2 family biology and biochemistry are reviewed that begin to address questions of how Bax and Bak breach the outer mitochondrial membrane remains poorly understood.
Journal ArticleDOI
Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3.
Chuanhai Fu,Kashif Ahmed,Husheng Ding,Xia Ding,Jianping Lan,Zhihong Yang,Yong Miao,Yuanyuan Zhu,Yunyu Shi,Jingde Zhu,He Huang,Xuebiao Yao,Xuebiao Yao +12 more
TL;DR: These studies provide first line of evidence showing that SUMO-3 is essential for PML localization and offer novel insight into the pathobiochemistry of APL.