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Andreas H. Jacobs
Researcher at University of Münster
Publications - 223
Citations - 15334
Andreas H. Jacobs is an academic researcher from University of Münster. The author has contributed to research in topics: Glioma & Positron emission tomography. The author has an hindex of 53, co-authored 212 publications receiving 13226 citations. Previous affiliations of Andreas H. Jacobs include Max Planck Society & Innovative Medicines Initiative.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
Role for neuronal insulin resistance in neurodegenerative diseases
Markus Schubert,Dinesh Gautam,David Surjo,Kazuhiro Ueki,S. Baudler,D. Schubert,Tatsuya Kondo,Jens Alber,Norbert Galldiks,Ekkehard Küstermann,Saskia S. Arndt,Andreas H. Jacobs,Wilhelm Krone,C R Kahn,Jens C. Brüning +14 more
TL;DR: Analysis of brain/neuron-specific insulin receptor knockout mice finds that NIRKO mice exhibit a complete loss of insulin-mediated activation of phosphatidylinositol 3-kinase and inhibition of neuronal apoptosis, which may lead to changes in Akt and GSK3β activity and Tau hyperphosphorylation.
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Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas
M. J. van den Bent,Jeffrey S. Wefel,David Schiff,Martin J.B. Taphoorn,Kurt A. Jaeckle,Larry Junck,Terri Armstrong,Terri Armstrong,A. Choucair,Adam D. Waldman,Thierry Gorlia,Marc C. Chamberlain,Brigitta G. Baumert,Michael A. Vogelbaum,David R. Macdonald,David A. Reardon,Patrick Y. Wen,Susan M. Chang,Andreas H. Jacobs +18 more
TL;DR: Clinical and imaging endpoints in trials of low-grade gliomas are investigated, response assessment in neuro-oncology (RANO) criteria for non-enhancing tumours is provided, and other measures for patients with brain tumours that assess outcome are described.
Journal ArticleDOI
Nosocomial Pneumonia After Acute Stroke Implications for Neurological Intensive Care Medicine
Ruediger Hilker,Carsten Poetter,Nahide Findeisen,Jan Sobesky,Andreas H. Jacobs,Michael Neveling,Wolf-Dieter Heiss +6 more
TL;DR: The data underline the considerable epidemiological and prognostic impact of SAP for the treatment of acute stroke patients in a specialized NICU setting and demonstrate that the occurrence of SAP deteriorates clinical outcome in these patients.
Journal ArticleDOI
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Andreas H. Jacobs,Juergen Voges,Regina Reszka,Martin J. Lercher,Axel Gossmann,Lutz W. Kracht,Ch Kaestle,Rainer Wagner,Klaus Wienhard,W.-D. Heiss +9 more
TL;DR: The extent of HSV-1-tk gene expression seemed to predict the therapeutic response, and the expression of an exogenous gene introduced by gene therapy into patients with gliomas can be monitored non-invasively by PET.