G
Gary E. Landreth
Researcher at Indiana University
Publications - 218
Citations - 34930
Gary E. Landreth is an academic researcher from Indiana University. The author has contributed to research in topics: Microglia & Neuroinflammation. The author has an hindex of 85, co-authored 202 publications receiving 30642 citations. Previous affiliations of Gary E. Landreth include Case Western Reserve University & University Hospitals of Cleveland.
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
Paige E. Cramer,John R. Cirrito,Daniel W. Wesson,Daniel W. Wesson,C. Y. Daniel Lee,J. Colleen Karlo,Adriana E. Zinn,Brad T. Casali,Jessica L. Restivo,Whitney D. Goebel,Michael J. James,Kurt R. Brunden,Donald A. Wilson,Gary E. Landreth +13 more
TL;DR: Oral administration of the RXR agonist bexarotene to a mouse model of AD resulted in enhanced clearance of soluble Aβ within hours in an apoE-dependent manner, and stimulated the rapid reversal of cognitive, social, and olfactory deficits and improved neural circuit function.
Journal ArticleDOI
ApoE Promotes the Proteolytic Degradation of Aβ
Qingguang Jiang,C. Y. Daniel Lee,Shweta Mandrekar,Brandy L. Wilkinson,Paige E. Cramer,Noam Zelcer,Karen Mann,Bruce T. Lamb,Timothy M. Willson,Jon L. Collins,Jill C. Richardson,Jonathan D. Smith,Thomas A. Comery,David Riddell,David M. Holtzman,Peter Tontonoz,Gary E. Landreth +16 more
TL;DR: Apolipoprotein E plays a role in facilitating the proteolytic clearance of soluble Abeta from the brain and LXR agonists may represent a novel therapy for AD.
Journal ArticleDOI
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis
TL;DR: A functional linkage between β-amyloid-dependent activation of microglia and several characteristic markers of neuronal death occurring in Alzheimer's disease brains is demonstrated.