O
Olga Garaschuk
Researcher at University of Tübingen
Publications - 104
Citations - 12778
Olga Garaschuk is an academic researcher from University of Tübingen. The author has contributed to research in topics: Microglia & Calcium imaging. The author has an hindex of 37, co-authored 92 publications receiving 10389 citations. Previous affiliations of Olga Garaschuk include Technische Universität München & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
Journal ArticleDOI
In vivo two-photon calcium imaging of neuronal networks
TL;DR: In vivo two-photon calcium imaging recordings indicated that whisker deflection-evoked Ca2+ transients occur in a subset of layer 2/3 neurons of the barrel cortex, demonstrating the suitability of this technique for real-time analyses of intact neuronal circuits with the resolution of individual cells.
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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.
Marc Aurel Busche,Gerhard Eichhoff,Gerhard Eichhoff,Helmuth Adelsberger,Helmuth Adelsberger,Dorothee Abramowski,Karl-Heinz Wiederhold,Christian Haass,Christian Haass,Matthias Staufenbiel,Arthur Konnerth,Arthur Konnerth,Olga Garaschuk,Olga Garaschuk +13 more
TL;DR: It is suggested that a redistribution of synaptic drive between silent and hyperactive neurons, rather than an overall decrease in synaptic activity, provides a mechanism for the disturbed cortical function in Alzheimer's disease.
Journal ArticleDOI
Brain tumour cells interconnect to a functional and resistant network
Matthias Osswald,Matthias Osswald,Erik Jung,Erik Jung,Felix Sahm,Felix Sahm,Gergely Solecki,Gergely Solecki,Varun Venkataramani,Jonas Blaes,Jonas Blaes,Sophie Weil,Sophie Weil,Heinz Horstmann,Benedikt Wiestler,Benedikt Wiestler,Benedikt Wiestler,Mustafa Syed,Mustafa Syed,Lulu Huang,Lulu Huang,Miriam Ratliff,Miriam Ratliff,Kianush Karimian Jazi,Kianush Karimian Jazi,Felix T. Kurz,Torsten Schmenger,Torsten Schmenger,Dieter Lemke,Dieter Lemke,Miriam Gömmel,Miriam Gömmel,Martin Pauli,Yunxiang Liao,Yunxiang Liao,Peter Häring,Stefan Pusch,Stefan Pusch,Verena Herl,Christian Steinhäuser,Damir Krunic,Mostafa Jarahian,Hrvoje Miletic,Anna S. Berghoff,Oliver Griesbeck,Georgios Kalamakis,Olga Garaschuk,Matthias Preusser,Samuel Weiss,Hai-Kun Liu,Sabine Heiland,Michael Platten,Michael Platten,Peter E. Huber,Peter E. Huber,Thomas Kuner,Andreas von Deimling,Andreas von Deimling,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +61 more
TL;DR: It is shown that many tumour cells in astrocytomas extend ultra-long membrane protrusions, and use these distinct tumour microtubes as routes for brain invasion, proliferation, and to interconnect over long distances, which develops functional multicellular network structures.
Journal ArticleDOI
Large-scale oscillatory calcium waves in the immature cortex.
TL;DR: A type of large-scale Ca2+ wave that may regulate long-distance wiring in the immature cortex is identified that is associated with field-potential changes and required activation of AMPA and NMDA receptors.