Nikolaus Deigendesch

TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.

TL;DR: It is shown that NETs are induced by mitogens and accompanied by induction of cell-cycle markers, including phosphorylation of the retinoblastoma protein and lamins, nuclear envelope breakdown, and duplication of centrosomes, and that the response is inhibited by the cell- cycle inhibitor p21Cip.

TL;DR: The results delineate IFN-I mediated oxidative stress as a key mediator of virus-induced liver damage and describe a mechanism of innate-immunity-driven pathology, linking IFn-I signaling with antioxidant host defense and infection-associated tissue damage.

TL;DR: This study showed that blocking IL–1 is safe in patients with ALS, and further trials should test whether targeting IL-1 more efficiently can help treating this devastating disease.

TL;DR: It is demonstrated that NLRP3 inflammasome activation is blocked by removing copper from the active site of superoxide dismutase 1, recapitulating impaired inflammaome function insuperoxide dismUTase 1–deficient mice, indicating that targeting the intracellular copper homeostasis has potential for the treatment ofNLRP3-dependent diseases.