Terrence Town

TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.

TL;DR: The data reveal that oxidized mtDNA released during programmed cell death causes activation of the NLRP3 inflammasome, and provides a missing link between apoptosis and inflammaome activation, via binding of cytosolic oxidizedmtDNA to the NL RP3 infammasome.

TL;DR: Tlr3-deficient mice were more resistant to lethal WNV infection and had impaired cytokine production and enhanced viral load in the periphery, whereas in the brain, viral load, inflammatory responses and neuropathology were reduced compared to wild-type mice.

TL;DR: An example of eukaryotic genes located on separate chromosomes associating physically in the nucleus via interactions that may have a function in coordinating gene expression is provided and there seems to be a cell-type-specific dynamic interaction between interacting chromatin partners whereby interchromosomal interactions are apparently lost in favour of intrachromosomal ones upon gene activation.

TL;DR: IL-17A-mediated protection in the CD45RBhi transfer model of colitis is demonstrated and T cells are identified as not only the source but also a target of IL-17 in vivo.