L
Luis G. Bermúdez-Humarán
Researcher at Université Paris-Saclay
Publications - 163
Citations - 13694
Luis G. Bermúdez-Humarán is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Lactococcus lactis & Immune system. The author has an hindex of 47, co-authored 149 publications receiving 10897 citations. Previous affiliations of Luis G. Bermúdez-Humarán include Institut national de la recherche agronomique & Universidad Autónoma de Nuevo León.
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Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI
Faecalibacterium prausnitzii and human intestinal health
Sylvie Miquel,Rebeca Martín,Rebeca Martín,Oriana Rossi,Luis G. Bermúdez-Humarán,Luis G. Bermúdez-Humarán,Jean-Marc Chatel,Jean-Marc Chatel,Harry Sokol,Muriel Thomas,Muriel Thomas,Jerry M. Wells,P. Langella,P. Langella +13 more
TL;DR: The role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved is discussed and its importance as a component of the healthy human microbiota is described.
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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
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Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease
Elodie Quévrain,Marie-Anne Maubert,Christophe Michon,Florian Chain,Florian Chain,Rodrigue Marquant,Rodrigue Marquant,Rodrigue Marquant,Julien Tailhades,Julien Tailhades,Julien Tailhades,Sylvie Miquel,Sylvie Miquel,Ludovic Carlier,Ludovic Carlier,Ludovic Carlier,Luis G. Bermúdez-Humarán,Luis G. Bermúdez-Humarán,Bénédicte Pigneur,Bénédicte Pigneur,Olivier Lequin,Olivier Lequin,Olivier Lequin,Pascale Kharrat,Pascale Kharrat,Ginette Thomas,Ginette Thomas,Dominique Rainteau,Camille Aubry,Camille Aubry,N. Breyner,N. Breyner,Carlos Afonso,Solange Lavielle,Solange Lavielle,Solange Lavielle,Jean-Pierre Grill,Jean-Pierre Grill,Gérard Chassaing,Gérard Chassaing,Gérard Chassaing,Jean-Marc Chatel,Jean-Marc Chatel,Germain Trugnan,Ramnik J. Xavier,P. Langella,P. Langella,Harry Sokol,Philippe Seksik +48 more
TL;DR: A 15 kDa protein with anti-inflammatory properties is produced by F. prausnitzii, a commensal bacterium involved in CD pathogenesis, and is able to inhibit the NF-κB pathway in intestinal epithelial cells and to prevent colitis in an animal model.
Journal ArticleDOI
Beneficial effects on host energy metabolism of short-chain fatty acids and vitamins produced by commensal and probiotic bacteria
Jean Guy LeBlanc,Florian Chain,Rebeca Martín,Luis G. Bermúdez-Humarán,Stéphanie Courau,Philippe Langella +5 more
TL;DR: It is shown that these vitamins and SCFA producing bacteria could be used as tools to recover energy intakes by either optimizing ATP production from foods or by the fermentation of certain fibers in the gastrointestinal tract (GIT).