C
Christelle Vachoux
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 833
Christelle Vachoux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Dextromethorphan & Intestinal absorption. The author has an hindex of 7, co-authored 7 publications receiving 708 citations. Previous affiliations of Christelle Vachoux include Paul Sabatier University.
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Journal ArticleDOI
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
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Changes in Lipoprotein Kinetics Associated With Type 2 Diabetes Affect the Distribution of Lipopolysaccharides Among Lipoproteins
Bruno Vergès,Laurence Duvillard,Laurent Lagrost,Christelle Vachoux,Céline Garret,Karine Bouyer,Michael Courtney,Céline Pomié,Rémy Burcelin +8 more
TL;DR: The data suggest that in humans, free LPS transfers first to HDL and then to V LDL, whereas the LPS-bound LDL fraction is mainly derived from VLDL catabolism; the latter may hence represent a LPS catabolic pathway.
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Validation of a liquid chromatography-mass spectrometry method to assess the metabolism of bupropion in rat everted gut sacs
TL;DR: The detection of dextrorphan and 3-methoxymorphinan showed that both the P450 isoforms CYP3A and 2D were active in the intestinal mucosa and metabolised dextromethorphan during its passage across the mucosa.
Journal Article
The metabolism of midazolam and comparison with other CYP enzyme substrates during intestinal absorption: in vitro studies with rat everted gut sacs.
TL;DR: Given that the everted rat gut sac model provides a useful tool to assess the role of metabolism during drug absorption by the intestine and is also capable of demonstrating P-glycoprotein mediated transport, this method enables drug metabolism to be studied during absorption.
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Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter
Guylène Lafforgue,Cécile Arellano,Christelle Vachoux,John F. Woodley,Claude Philibert,Véronique Dupouy,Alain Bousquet-Mélou,Peggy Gandia,Georges Houin +8 more
TL;DR: It is suggested that paracellular diffusion is the major mechanism of absorption, at least for β‐lactam antibiotics with poor bioavailability, such as ampicillin, and that the use of Caco‐2 cells underestimates the role of the parACEllular route in the absorption of hydrophilic drugs in vivo, and may exaggerate the roles of influx transporters.