P
Philippe Langella
Researcher at Institut national de la recherche agronomique
Publications - 194
Citations - 16295
Philippe Langella is an academic researcher from Institut national de la recherche agronomique. The author has contributed to research in topics: Lactococcus lactis & Medicine. The author has an hindex of 58, co-authored 160 publications receiving 13539 citations. Previous affiliations of Philippe Langella include University of Paris & Agro ParisTech.
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Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands
Bruno Lamas,Mathias L. Richard,Valentin Leducq,Hang-Phuong Pham,Marie-Laure Michel,Grégory Da Costa,Chantal Bridonneau,Sarah Jegou,Thomas W. Hoffmann,Jane M. Natividad,Loic Brot,Soraya Taleb,Soraya Taleb,Aurélie Couturier-Maillard,Isabelle Nion-Larmurier,Fatiha Merabtene,Philippe Seksik,Anne Bourrier,Jacques Cosnes,Bernhard Ryffel,Bernhard Ryffel,Laurent Beaugerie,Jean-Marie Launay,Philippe Langella,Ramnik J. Xavier,Harry Sokol +25 more
TL;DR: In this article, a relationship between the host and the gut microbiota govern intestinal homeostasis is revealed, and the authors reveal that host genes affect the composition and function of the Gut microbiota, altering the production of microbial metabolites and intestinal inflammation.
Journal ArticleDOI
Microbial dysbiosis in colorectal cancer (CRC) patients.
Iradj Sobhani,Julien Tap,Françoise Roudot-Thoraval,Jean Pierre Roperch,Sophie Letulle,Philippe Langella,Gérard Corthier,Jeanne Tran Van Nhieu,Jean Pierre Furet +8 more
TL;DR: This is the first large series to demonstrate a composition change in the microbiota of colon cancer patients with possible impact on mucosal immune response and 80% of all sequences could be assigned to a total of 819 taxa based on default parameter of Classifier software.
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Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
Journal ArticleDOI
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
Henri Duboc,Sylvie Rajca,Sylvie Rajca,Dominique Rainteau,Dominique Rainteau,David Benarous,Marie-Anne Maubert,Marie-Anne Maubert,Elodie Quervain,Elodie Quervain,Ginette Thomas,Ginette Thomas,Véronique Barbu,Lydie Humbert,Lydie Humbert,Guillaume Despras,Chantal Bridonneau,Fabien Dumetz,Jean-Pierre Grill,Jean-Pierre Grill,Joëlle Masliah,Joëlle Masliah,Laurent Beaugerie,Laurent Beaugerie,Jacques Cosnes,Jacques Cosnes,Olivier Chazouillères,Raoul Poupon,Claude Wolf,Jean-Maurice Mallet,Philippe Langella,Germain Trugnan,Germain Trugnan,Harry Sokol,Harry Sokol,Philippe Seksik,Philippe Seksik +36 more
TL;DR: Altered BA transformation in the gut lumen can erase the anti-inflammatory effects of some BA species on gut epithelial cells and could participate in the chronic inflammation loop of IBD.