P
Pascale Klopp
Researcher at French Institute of Health and Medical Research
Publications - 13
Citations - 2412
Pascale Klopp is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Gut flora & Dysbiosis. The author has an hindex of 10, co-authored 13 publications receiving 2001 citations. Previous affiliations of Pascale Klopp include University of Toulouse & Paul Sabatier University.
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Journal ArticleDOI
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment
Jacques Amar,Chantal Chabo,Aurélie Waget,Pascale Klopp,Christelle Vachoux,Luis G. Bermúdez-Humarán,Natalia F. Smirnova,Mathieu Bergé,Mathieu Bergé,Thierry Sulpice,Sampo J. Lahtinen,Arthur C. Ouwehand,Philippe Langella,Nina Rautonen,Philippe J. Sansonetti,Rémy Burcelin +15 more
TL;DR: It is demonstrated that the early onset of HFD‐induced hyperglycemia is characterized by an increased bacterial translocation from intestine towards tissues, fuelling a continuous metabolic bacteremia, which could represent new therapeutic targets.
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Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Matteo Serino,Elodie Luche,Sandra Grès,Audrey Baylac,Mathieu Bergé,Claire Cenac,Aurélie Waget,Pascale Klopp,Jason S. Iacovoni,Christophe Klopp,Jérôme Mariette,Olivier Bouchez,Jérôme Lluch,Françoise Ouarné,Pierre Monsan,Philippe Valet,Christine Roques,Jacques Amar,Anne Bouloumié,Vassilia Theodorou,Rémy Burcelin +20 more
TL;DR: The HFD-D gut microbial profile was associated with increased gut permeability linked to increased endotoxaemia and to a dramatic increase in cell number in the stroma vascular fraction from visceral white adipose tissue.
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Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept
Jacques Amar,Matteo Serino,Céline Lange,Chantal Chabo,Jason S. Iacovoni,Stanislas Mondot,Patricia Lepage,Christophe Klopp,Jérôme Mariette,Olivier Bouchez,L. Perez,Michael Courtney,Michel Marre,Pascale Klopp,Olivier Lantieri,Joël Doré,Marie-Aline Charles,B. Balkau,Rémy Burcelin +18 more
TL;DR: 16S rDNA was shown to be an independent marker of the risk of diabetes, evidence for the concept that tissue bacteria are involved in the onset of diabetes in humans.
Journal ArticleDOI
The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.
Lucile Garidou,Lucile Garidou,Céline Pomié,Céline Pomié,Pascale Klopp,Pascale Klopp,Aurélie Waget,Aurélie Waget,Julie Charpentier,Julie Charpentier,Meryem Aloulou,Meryem Aloulou,Meryem Aloulou,Anaïs Giry,Anaïs Giry,Matteo Serino,Matteo Serino,Lotta Stenman,Sampo J. Lahtinen,Cédric Dray,Cédric Dray,Jason S. Iacovoni,Michael Courtney,Xavier Collet,Xavier Collet,Jacques Amar,Florence Servant,Benjamin Lelouvier,Philippe Valet,Philippe Valet,Gérard Eberl,Nicolas Fazilleau,Nicolas Fazilleau,Nicolas Fazilleau,Victorine Douin-Echinard,Victorine Douin-Echinard,Christophe Heymes,Christophe Heymes,Rémy Burcelin,Rémy Burcelin +39 more
TL;DR: It is shown that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice, and it is concluded that the microbiota of the ilesum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease.
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Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response
Vincent Blasco-Baque,Lucile Garidou,Lucile Garidou,Céline Pomié,Céline Pomié,Quentin Escoula,Quentin Escoula,Pascale Loubieres,Sandrine Le Gall-David,Mathieu Lemaitre,Simon Nicolas,Simon Nicolas,Pascale Klopp,Pascale Klopp,Aurélie Waget,Aurélie Waget,Vincent Azalbert,Vincent Azalbert,André Colom,André Colom,Martine Bonnaure-Mallet,Philippe Kémoun,Matteo Serino,Matteo Serino,Rémy Burcelin,Rémy Burcelin +25 more
TL;DR: It is identified that insulin resistance in the high-fat fed mouse is enhanced by pathogen-induced periodontitis, caused by an adaptive immune response specifically directed against pathogens and associated with a periodontal dysbiosis.