E
Erdenechimeg Shagdarsuren
Researcher at RWTH Aachen University
Publications - 40
Citations - 5473
Erdenechimeg Shagdarsuren is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Angiotensin II & Renin–angiotensin system. The author has an hindex of 28, co-authored 40 publications receiving 5151 citations. Previous affiliations of Erdenechimeg Shagdarsuren include Hannover Medical School & University of Helsinki.
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Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
Journal ArticleDOI
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.
Limor Landsman,Liat Bar-On,Alma Zernecke,Ki-Wook Kim,Rita Krauthgamer,Erdenechimeg Shagdarsuren,Sergio A. Lira,Irving L. Weissman,Christian Weber,Steffen Jung +9 more
TL;DR: It is shown that enforced survival of monocytes and plaque-resident phagocytes, including foam cells, restored atherogenesis in CX(3)CR1-deficent mice and introduced a Bcl2 transgene, suggesting that the CX (3)C axis provides an essential survival signal.
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Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis
Alma Zernecke,Ilze Bot,Yassin Djalali-Talab,Erdenechimeg Shagdarsuren,Kiril Bidzhekov,Svenja Meiler,Regina M. Krohn,Andreas Schober,Markus Sperandio,Oliver Soehnlein,Jörg Bornemann,Frank Tacke,Erik A.L. Biessen,Christian Weber +13 more
TL;DR: It is shown that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic CxCr4 deficiency, or lentiviral transduction with CXcr4 degrakine in bone marrow chimeras aggravated diet-induced atherosclerosis in apolipoprotein E-deficient or LDL receptor–deficient mice.
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Chemokines in Atherosclerosis: An Update
TL;DR: This update will highlight the identification of components regulating the transcriptional machinery of the proatherogenic chemokine CCL5, distinct roles of its receptors CCR1 and CCR5 in plaque formation and immunobalance, and differential site- and stage-specific effects of T cell–activating chemokines and their receptors.
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Immunosuppressive treatment protects against angiotensin II-induced renal damage.
Dominik N. Müller,Dominik N. Müller,Erdenechimeg Shagdarsuren,Joon-Keun Park,Ralf Dechend,Eero Mervaala,Franziska Hampich,Anette Fiebeler,Xinsheng Ju,Piet Finckenberg,Jürgen Theuer,Jürgen Theuer,Christiane Viedt,Joerg Kreuzer,Harald Heidecke,Hermann Haller,Martin Zenke,Friedrich C. Luft +17 more
TL;DR: It is suggested that immunosuppression prevents dendritic cell maturation and T-cell infiltration in a nonimmune model of Ang II-induced renal damage, which may initiate events leading to innate and acquired immune response.