Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TLDR
It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.Abstract:
Apoptosis is a pivotal process in embryogenesis and postnatal cell homeostasis and involves the shedding of membranous microvesicles termed apoptotic bodies. In response to tissue damage, the CXC chemokine CXCL12 and its receptor CXCR4 counteract apoptosis and recruit progenitor cells. Here, we show that endothelial cell-derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12. CXCL12 production was mediated by microRNA-126 (miR-126), which was enriched in apoptotic bodies and repressed the function of regulator of G protein (heterotrimeric guanosine triphosphate-binding protein) signaling 16, an inhibitor of G protein-coupled receptor (GPCR) signaling. This enabled CXCR4, a GPCR, to trigger an autoregulatory feedback loop that increased the production of CXCL12. Administration of apoptotic bodies or miR-126 limited atherosclerosis, promoted the incorporation of Sca-1+ progenitor cells, and conferred features of plaque stability on different mouse models of atherosclerosis. This study highlights functions of microRNAs in health and disease that may extend to the recruitment of progenitor cells during other forms of tissue repair or homeostasis.read more
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Journal ArticleDOI
Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection : a case control study
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Nonenoy,B. Piyavong,Wisit Prasithsirikul,Phitsanu Raksakulkarn,Brian Gazzard,Jonathan Ainsworth,B. J. Angus,Tristan Barber,M. G. Brook,C. D. Care,David R. Chadwick,M. Chikohora,Duncan Churchill,D. Cornforth,D. H. Dockrell,Philippa Easterbrook,Penny Fox,P. A. Gomez,Mark Gompels,G. M. Harris,Stephen J. Herman,Akil Jackson,S. P.R. Jebakumar,G. R. Kinghorn,K. A. Kuldanek,N. Larbalestier,M. Lumsden,T. Maher,J. Mantell,L. Muromba,Chloe Orkin,S. Peters,Tim E. A. Peto,Simon Portsmouth,S. Rajamanoharan,Ronan,Achim Schwenk,M. A. Slinn,C. J. Stroud,R. C. Thomas,M. H. Wansbrough-Jones,H. J. Whiles,David White,E. Williams,G. Williams,M Youle,Donald I. Abrams,E. A. Acosta,A. Adamski,D. Antoniskis,D. R. Aragon,Ben J. Barnett,C. Baroni,M. Barron,John D. Baxter,D. Beers,M. Beilke,Bemenderfer,A. Bernard,Camille Besch,M. T. Bessesen,J. T. Bethel,S. Blue,J. D. Blum,S. Boarden,Robert K. Bolan,J. B. Borgman,Indira Brar,B. K. Braxton,U. F. Bredeek,R. Brennan,D. E. Britt,D. Bulgin-Coleman,E. Bullock,B. Campbell,S. Caras,J. Carroll,K. K. Casey,F. Chiang,R. B. Cindrich,Cal Cohen,J. Coley,D. V. Condoluci,R. Contreras,J. Corser,J. Cozzolino,Lawrence R. Crane,L. Daley,D. Dandridge,V. D'Antuono,J. G. Darcourt Rizo Patron,J. A. DeHovitz,Edwin DeJesus,J. DesJardin,C. Dietrich,A. Dolce,D. Erickson,L. L. Faber,J. Falbo,M. J. Farrough,Charles Farthing,P. Ferrell-Gonzalez,H. Flynn,M. Frank,K. F. Freeman,N. French,Gerald Friedland,N. Fujita,L. Gahagan,I. Gilson,Matthew Bidwell Goetz,E. Goodwin,C. K. Guity,P. Gulick,E. R. Gunderson,C. M. Hale,K. Hannah,H. Henderson,K. Hennessey,W. K. Henry,T. Higgins,Sally Hodder,H. W. Horowitz,M. Howe-Pittman,J. Hubbard,R. Hudson,H. Hunter,C. Hutelmyer,M. T. Insignares,Lois A. Jackson,L. Jenny,D. L. Johnson,G. Johnson,Jeffrey A. Johnson,J. Kaatz,J. Kaczmarski,S. Kagan,C. Kantor,T. Kempner,K. Kieckhaus,N. Kimmel,B. M. Klaus,J. R. Koeppe,Janak Koirala,J. Kopka,J. R. Kostman,Michael J. Kozal,Ashok Kumar,Harry Lampiris,C. Lamprecht,K. M. Lattanzi,J. Lee,J. Leggett,C. Long,A. Loquere,K. Loveless,C. Lucasti,R. Luskin-Hawk,M. MacVeigh,L. H. Makohon,Norman Markowitz,C. Marks,Claudia Martorell,E. McFeaters,B. McGee,D. M. McIntyre,E. McManus,L. G. Melecio,D. Melton,S. Mercado,E. Merrifield,J. A. Mieras,M. Mogyoros,F. M. Moran,Kellie E. Murphy,S. Mutic,I. Nadeem,J. P. Nadler,A. Ognjan,Mary O'Hearn,K. O'Keefe,P. C. Okhuysen,E. Oldfield,D. Olson,R. Orenstein,Roberto Ortiz,F. Parpart,V. Pastore-Lange,S. Paul,A. Pavlatos,D. D. Pearce,R. Pelz,S. Peterson,D. Pitrak,S. L. Powers,H. C. Pujet,J. W. Raaum,J. Ravishankar,J. Reeder,N. A. Reilly,C. Reyelt,J. Riddell,David Rimland,M. L. Robinson,Allen E. Rodriguez,V. Rodriguez Derouen,C. Rosmarin,W. L. Rossen,J. R. Rouff,M. Sands,C. Savini,Shannon Schrader,M. M. Schulte,R. Scott,H. Seedhom,Michael Sension,A. ShebleHall,Jonathan Shuter,Leonard N. Slater,R. Slotten,Miranda Zoe Denham Smith,S. Snap,D. M. States,G. Stringer,K. K. Summers,K. Swanson,I. B. Sweeton,S. Szabo,Ellen Tedaldi,Edward E. Telzak,Melanie A. Thompson,Sandra C. Thompson,C. Ting Hong Bong,A. Vaccaro,L. M. Vasco,I. Vecino,G. K. Verlinghieri,Fehmida Visnegarwala,H. Wade,Stephen E. Weis,J. A. Weise,S. Weissman,M. Wilkin,J. H. Witter,L. Wojtusic,T. J. Wright,V. Yeh,B. Young,C. Zeana,J. Zeh,E. Savio,M. Vacarezza +1489 more
TL;DR: No associations with mortality were found with any circulating miRNAs studied and these results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.
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Atherosclerosis: current pathogenesis and therapeutic options
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TL;DR: This work aims to systematically survey recently identified molecular mechanisms, translational developments and clinical strategies for targeting lipid-related inflammation in atherosclerosis and CAD.
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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells
Nobuyoshi Kosaka,Haruhisa Iguchi,Yusuke Yoshioka,Fumitaka Takeshita,Yasushi Matsuki,Takahiro Ochiya +5 more
TL;DR: It is shown that miRNAs are released through a ceramide-dependent secretory machinery and that the secretory miRNAAs are transferable and functional in the recipient cells and that a tumor-suppressive miRNA secreted via this pathway was transported between cells and exerted gene silencing in the recipients cells, thereby leading to cell growth inhibition.
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Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
María Mittelbrunn,Cristina Gutiérrez-Vázquez,Carolina Villarroya-Beltri,Susana González,Fátima Sánchez-Cabo,Manuel A. González,Antonio Bernad,Francisco Sánchez-Madrid +7 more
TL;DR: It is shown that exosomes of T, B and dendritic immune cells contain microRNA (miRNA) repertoires that differ from those of their parent cells, and that miRNAs transferred during immune synapsis are able to modulate gene expression in recipient cells.
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