K
Kiril Bidzhekov
Researcher at Ludwig Maximilian University of Munich
Publications - 35
Citations - 6042
Kiril Bidzhekov is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammation & Chemokine. The author has an hindex of 25, co-authored 32 publications receiving 5149 citations. Previous affiliations of Kiril Bidzhekov include RWTH Aachen University & Max Planck Society.
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Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
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Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases
Steffen Massberg,Lenka Grahl,Marie-Luise von Bruehl,Davit Manukyan,Susanne Pfeiler,Christian Goosmann,Volker Brinkmann,Michael Lorenz,Kiril Bidzhekov,Avinash Khandagale,Ildiko Konrad,Elisabeth Kennerknecht,Katja Reges,Stefan Holdenrieder,Siegmund Braun,Christoph Reinhardt,Michael Spannagl,Klaus T. Preissner,Bernd Engelmann +18 more
TL;DR: The ability of coagulation to suppress pathogen dissemination indicates that microvessel thrombosis represents a physiological tool of host defense, although the molecular determinants and in vivo significance of this association remain unclear.
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Andreas Schober,Maliheh Nazari-Jahantigh,Yuanyuan Wei,Kiril Bidzhekov,Felix Gremse,Jochen Grommes,Remco T. A. Megens,Kathrin Heyll,Heidi Noels,Michael Hristov,Shusheng Wang,Fabian Kiessling,Eric N. Olson,Christian Weber +13 more
TL;DR: It is shown that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation and introduces a potential therapeutic approach.
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Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis
Alma Zernecke,Ilze Bot,Yassin Djalali-Talab,Erdenechimeg Shagdarsuren,Kiril Bidzhekov,Svenja Meiler,Regina M. Krohn,Andreas Schober,Markus Sperandio,Oliver Soehnlein,Jörg Bornemann,Frank Tacke,Erik A.L. Biessen,Christian Weber +13 more
TL;DR: It is shown that interference with Cxcl12/Cxcr4 by a small-molecule antagonist, genetic CxCr4 deficiency, or lentiviral transduction with CXcr4 degrakine in bone marrow chimeras aggravated diet-induced atherosclerosis in apolipoprotein E-deficient or LDL receptor–deficient mice.
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Neutrophil secretion products pave the way for inflammatory monocytes
Oliver Soehnlein,Alma Zernecke,Einar E. Eriksson,Antonio Gigliotti Rothfuchs,Christine T.N. Pham,Heiko Herwald,Kiril Bidzhekov,Martin E. Rottenberg,Christian Weber,Lennart Lindbom +9 more
TL;DR: Data show that LL-37 and HBP specifically stimulate mobilization of inflammatory monocytes via activation of formyl-peptide receptors, which results in enhanced cytokine levels and increased bacterial clearance, thus boosting the early immune response.