E
Esther Lutgens
Researcher at University of Amsterdam
Publications - 102
Citations - 10710
Esther Lutgens is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 41, co-authored 82 publications receiving 9487 citations. Previous affiliations of Esther Lutgens include Katholieke Universiteit Leuven & VU University Medical Center.
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Journal ArticleDOI
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Peter Carmeliet,Maria Grazia Lampugnani,Lieve Moons,F. Breviario,Veerle Compernolle,Françoise Bono,Giovanna Balconi,Raffaella Spagnuolo,Bert Oosthuyse,Mieke Dewerchin,Adriana Zanetti,Anne Angellilo,Virginie Mattot,Dieter Nuyens,Esther Lutgens,Frédéric Clotman,Marco C. De Ruiter,Adriana Gittenberger De Groot,Robert E. Poelmann,Florea Lupu,Jean Marc Herbert,Desire Collen,Elizabetta Dejana,Elizabetta Dejana +23 more
TL;DR: Targeted inactivation or truncation of the beta-catenin-binding cytosolic domain of the VE-cadherin gene was found to affect assembly of endothelial cells in vascular plexi, but to impair their subsequent remodeling and maturation, causing lethality at 9.5 days of gestation.
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Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
Journal ArticleDOI
Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques
C.R. Dhore,Jack P.M. Cleutjens,Esther Lutgens,Kitty B.J.M. Cleutjens,Piet Geusens,Peter J.E.H.M. Kitslaar,Jan H.M. Tordoir,Henri M. H. Spronk,Cees Vermeer,Mat J.A.P. Daemen +9 more
TL;DR: The observed expression patterns suggest a tight regulation of the expression of bone matrix regulatory proteins during human atherogenesis, which might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification.
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Distribution of macrophage polarization markers in human atherosclerosis
J. Lauran Stöger,Marion J.J. Gijbels,Marion J.J. Gijbels,Saskia van der Velden,Marco Manca,Chris M. van der Loos,Erik A.L. Biessen,Mat J.A.P. Daemen,Esther Lutgens,Menno P.J. de Winther +9 more
TL;DR: M1 and M2 macrophage populations are present throughout atherogenesis and these subsets display disparity when it comes to their prevalence in morphological compartments of the vessel wall, warranting continued investigation into the functional implications of polarization populations in human atherosclerosis.
Journal ArticleDOI
Requirement for CD154 in the progression of atherosclerosis.
Esther Lutgens,Leonid Gorelik,Mat J.A.P. Daemen,de Muinck Ed,Iqbal S. Grewal,Victor Koteliansky,Richard A. Flavell +6 more
TL;DR: The data indicate that CD40–CD154 signaling is important in late atherosclerotic changes, such as lipid core formation and plaque destabilization.