H
Heidi Noels
Researcher at RWTH Aachen University
Publications - 66
Citations - 5968
Heidi Noels is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Medicine & Kidney disease. The author has an hindex of 20, co-authored 52 publications receiving 5014 citations. Previous affiliations of Heidi Noels include The Catholic University of America & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Atherosclerosis: current pathogenesis and therapeutic options
Christian Weber,Heidi Noels +1 more
TL;DR: This work aims to systematically survey recently identified molecular mechanisms, translational developments and clinical strategies for targeting lipid-related inflammation in atherosclerosis and CAD.
Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
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MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Andreas Schober,Maliheh Nazari-Jahantigh,Yuanyuan Wei,Kiril Bidzhekov,Felix Gremse,Jochen Grommes,Remco T. A. Megens,Kathrin Heyll,Heidi Noels,Michael Hristov,Shusheng Wang,Fabian Kiessling,Eric N. Olson,Christian Weber +13 more
TL;DR: It is shown that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation and introduces a potential therapeutic approach.
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MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages
Maliheh Nazari-Jahantigh,Yuanyuan Wei,Heidi Noels,Shamima Akhtar,Zhe Zhou,Rory R. Koenen,Kathrin Heyll,Felix Gremse,Fabian Kiessling,Jochen Grommes,Christian Weber,Andreas Schober +11 more
TL;DR: It is demonstrated that miR-155 plays a key role in atherogenic programming of macrophages to sustain and enhance vascular inflammation.
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The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
TL;DR: Insight is provided into the current concept of the CXCL12/CX CR4 axis in myocardial infarction and its underlying pathologies such as atherosclerosis and injury-induced vascular restenosis and a potential translation of current knowledge on CXCR4 into future therapeutical application is discussed.