S
Shusheng Wang
Researcher at Tulane University
Publications - 70
Citations - 7150
Shusheng Wang is an academic researcher from Tulane University. The author has contributed to research in topics: Angiogenesis & Macular degeneration. The author has an hindex of 31, co-authored 65 publications receiving 6160 citations. Previous affiliations of Shusheng Wang include University of Texas System & University of Texas at Dallas.
Papers
More filters
Journal ArticleDOI
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Shusheng Wang,Arin B. Aurora,Brett A. Johnson,Xiaoxia Qi,John McAnally,Joseph A. Hill,James A. Richardson,Rhonda S Bassel-Duby,Eric N. Olson +8 more
TL;DR: It is shown that an endothelial cell-restricted microRNA (miR-126) mediates developmental angiogenesis in vivo and enhances the proangiogenic actions of VEGF and FGF and promotes blood vessel formation by repressing the expression of Spred-1, an intracellular inhibitor of angiogenic signaling.
Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
Journal ArticleDOI
MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1
Andreas Schober,Maliheh Nazari-Jahantigh,Yuanyuan Wei,Kiril Bidzhekov,Felix Gremse,Jochen Grommes,Remco T. A. Megens,Kathrin Heyll,Heidi Noels,Michael Hristov,Shusheng Wang,Fabian Kiessling,Eric N. Olson,Christian Weber +13 more
TL;DR: It is shown that endothelial miR-126-5p maintains a proliferative reserve in ECs through suppression of the Notch1 inhibitor delta-like 1 homolog (Dlk1) and thereby prevents atherosclerotic lesion formation and introduces a potential therapeutic approach.
Journal ArticleDOI
AngiomiRs--key regulators of angiogenesis.
Shusheng Wang,Eric N. Olson +1 more
TL;DR: Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach in regulating endothelial cell function, especially angiogenesis.
Journal ArticleDOI
Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters
TL;DR: It is demonstrated that miRNAs encoded by the miR-23∼27∼24 gene clusters are enriched in endothelial cells and highly vascularized tissues, which may have important therapeutic implications in neovascular age-related macular degeneration and other vascular disorders.