L
Lin Gan
Researcher at RWTH Aachen University
Publications - 14
Citations - 1679
Lin Gan is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Angiotensin receptor & microRNA. The author has an hindex of 9, co-authored 14 publications receiving 1508 citations.
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Journal ArticleDOI
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection
Alma Zernecke,Kiril Bidzhekov,Heidi Noels,Erdenechimeg Shagdarsuren,Lin Gan,Bernd Denecke,Mihail Hristov,Thomas Köppel,Maliheh Nazari Jahantigh,Esther Lutgens,Esther Lutgens,Shusheng Wang,Eric N. Olson,Andreas Schober,Christian Weber,Christian Weber +15 more
TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.
Journal ArticleDOI
Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions.
Tim Clarner,Felix Diederichs,Katharina Berger,Bernd Denecke,Lin Gan,Paul van der Valk,Cordian Beyer,Sandra Amor,Sandra Amor,Markus Kipp +9 more
TL;DR: The studies show that the magnitude of myelin loss positively correlates with microgliosis in the cuprizone model, and the number of MHC class II expressing cells is higher in the white compared with the grey matter part of leucocortical lesions in MS.
Journal ArticleDOI
microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans
Kiril Bidzhekov,Lin Gan,Bernd Denecke,André Rostalsky,Mihail Hristov,Thomas A. Koeppel,Alma Zernecke,Christian Weber +7 more
TL;DR: In this article, the authors examined the miRNA signature of human classical and non-classical monocytes, and compared miRNA expression profiles of atherosclerotic plaques from human carotid arteries and healthy arteries.
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BLBP-expression in astrocytes during experimental demyelination and in human multiple sclerosis lesions
Markus Kipp,Stefan Gingele,Friederike Pott,Tim Clarner,P. van der Valk,Bernd Denecke,Lin Gan,Volker Siffrin,Frauke Zipp,Wolfgang Dreher,Werner Baumgartner,S. Pfeifenbring,Roseline Godbout,Sandra Amor,Sandra Amor,Cordian Beyer +15 more
TL;DR: Evidence is provided that expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure, and shows weak expression of the radial-glia cell marker brain lipid binding protein (BLBP).
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Transcriptome analysis of MSC and MSC-derived osteoblasts on Resomer® LT706 and PCL: impact of biomaterial substrate on osteogenic differentiation.
Sabine Neuss,Bernd Denecke,Lin Gan,Qiong Lin,Manfred Bovi,Christian Apel,Michael Wöltje,Anandhan Dhanasingh,Jochen Salber,Jochen Salber,Ruth Knüchel,Martin Zenke +11 more
TL;DR: This study demonstrates an enhanced osteogenic differentiation of MSC on Resomer® LT706 and PCL compared to tissue culture polystyrene (TCPS), a particularly attractive scaffold material for bone tissue engineering.