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Kei Matsueda

Researcher at University of Chicago

Publications -  44
Citations -  1458

Kei Matsueda is an academic researcher from University of Chicago. The author has contributed to research in topics: Acotiamide & Irritable bowel syndrome. The author has an hindex of 15, co-authored 44 publications receiving 1387 citations.

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Epidemiologic analysis of Crohn disease in Japan: increased dietary intake of n-6 polyunsaturated fatty acids and animal protein relates to the increased incidence of Crohn disease in Japan.

TL;DR: It is suggested that increased dietary intake of animal protein and n-6 polyunsaturated fatty acids with less n-3 polyuns saturated fatty acids may contribute to the development of Crohn disease.
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Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits.

TL;DR: The mucosal 5-HT concentrations in the colon showed an ascending cephalocaudal gradient in all study groups and further studies are necessary to determine whether the elevated mucosal5-HT is a cause or a result of abnormal colonic motility.
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A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome.

TL;DR: Ramosetron hydrochloride 5 µg once daily is effective and well tolerated in the treatment of abdominal pain, discomfort and bowel habits in patients with diarrhea-predominant irritable bowel syndrome.
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A phase II trial of the novel serotonin type 3 receptor antagonist ramosetron in Japanese male and female patients with diarrhea-predominant irritable bowel syndrome.

TL;DR: Ramosetron is an effective and well-tolerated treatment not only for female IBS patients but also for male patients and there was tolerability at doses up to 10 µg.