S
Shozo Baba
Researcher at Hamamatsu University School of Medicine
Publications - 113
Citations - 5088
Shozo Baba is an academic researcher from Hamamatsu University School of Medicine. The author has contributed to research in topics: Cancer & Hepatectomy. The author has an hindex of 31, co-authored 113 publications receiving 4967 citations. Previous affiliations of Shozo Baba include Hamamatsu University.
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Journal ArticleDOI
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
Isamu Nishisho,Yusuke Nakamura,Yasuo Miyoshi,Yoshio Miki,Hiroshi Ando,Akira Horii,Kumiko Koyama,Joji Utsunomiya,Shozo Baba,Hedge Philip John,Alex Markham,Anne J. Krush,Gloria M. Petersen,Stanley R. Hamilton,Mef Nilbert,Daniel B. Levy,Tracy M. Bryan,Antonette C. Preisinger,Kelly J. Smith,Li Kuo Su,Kenneth W. Kinzler,Bert Vogelstein +21 more
TL;DR: The data suggest that more than one gene on chromosome 5q21 may contribute to colorectal neoplasia, and that mutations of the APC gene can cause both FAP and GS.
Journal Article
Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis patients.
Hiroki Nagase,Hiroki Nagase,Yasuo Miyoshi,Akira Horii,Takahisa Aoki,Michio Ogawa,Joji Utsunomiya,Shozo Baba,Takehiko Sasazuki,Yusuke Nakamura +9 more
TL;DR: The result suggests that the number of colorectal polyps in FAP patients may be associated with a difference in the stability or biological function of the truncated APC protein.
Journal ArticleDOI
Safety and efficacy of granulocyte and monocyte adsorption apheresis in patients with active ulcerative colitis: a multicenter study.
Takashi Shimoyama,Koji Sawada,Nobuo Hiwatashi,Toshio Sawada,Kei Matsueda,Akihiro Munakata,Hitoshi Asakura,Takao Tanaka,Reiji Kasukawa,Ken Kimura,Yasuo Suzuki,Yukio Nagamachi,Tetsuichiro Muto,Hirokazu Nagawa,Bunei Iizuka,Shozo Baba,Masaru Nasu,Tatsuji Kataoka,Nobuhito Kashiwagi,Abby R. Saniabadi +19 more
TL;DR: Based on the results, it is believed that in patients with active severe UC, patients who are refractory to conventional drugs, granulocyte and monocyte adsorption apheresis is a useful adjunct to conventional therapy.
Journal ArticleDOI
Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC)
TL;DR: The results indicated that hMLH1 consists of 19 coding exons spanning approximately 100 kb, and that exons 1-7 contain a region that is highly conserved in the MLH1 and PMS1 genes of yeast.
Journal ArticleDOI
Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients
Hiroki Nagase,Hiroki Nagase,Yasuo Miyoshi,Akira Horii,Takahisa Aoki,Gloria M. Petersen,Bert Vogelstein,Eamonn R. Maher,Michio Ogawa,Masakazu Maruyama,Joji Utsunomiya,Shozo Baba,Yusuke Nakamura +12 more
TL;DR: Examination of the entire coding region of the APC gene, based on a ribonuclease protection assay coupled with the polymerase chain reaction (PCR), disclosed mutations that were considered to cause significant defects in theAPC product in 97 of 150 unrelated FAP patients.