European prospective investigation into cancer and nutrition (EPIC): study populations and data collection
Elio Riboli,Kelly J. Hunt,Nadia Slimani,Pietro Ferrari,Teresa Norat,Michael T. Fahey,Charrondière Ur,Bertrand Hémon,Corinne Casagrande,Jérôme Vignat,Kim Overvad,Anne Tjønneland,Françoise Clavel-Chapelon,Anne C. M. Thiébaut,Jürgen Wahrendorf,Heiner Boeing,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Antonia Trichopoulou,Paolo Vineis,Domenico Palli,H. B. Bueno-De-Mesquita,Petra H.M. Peeters,Eiliv Lund,Dagrun Engeset,Carlos A. González,Aurelio Barricarte,Göran Berglund,Göran Hallmans,Nicholas E. Day,Timothy J. Key,Rudolf Kaaks,R. Saracci +32 more
TLDR
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.Abstract:
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrollment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.read more
Citations
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The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
Gijs den Besten,Karen van Eunen,Albert K. Groen,Koen Venema,Dirk-Jan Reijngoud,Barbara M. Bakker +5 more
TL;DR: This review summarizes the role of SCFAs in host energy metabolism, starting from the production by the gut microbiota to the uptake by the host and ending with the effects on host metabolism.
Journal ArticleDOI
General and abdominal adiposity and risk of death in Europe.
Tobias Pischon,Heiner Boeing,Kurt Hoffmann,M. Bergmann,Matthias B. Schulze,Kim Overvad,Y. T. van der Schouw,Elizabeth A Spencer,Karel G.M. Moons,Anne Tjønneland,Jytte Halkjær,Majken K. Jensen,Jakob Stegger,Françoise Clavel-Chapelon,M. C. Boutron-Ruault,V. Chajes,Jakob Linseisen,Rudolf Kaaks,Antonia Trichopoulou,Dimitrios Trichopoulos,Christina Bamia,Sabina Sieri,Domenico Palli,Rosario Tumino,Paolo Vineis,Paolo Vineis,Salvatore Panico,Petra H.M. Peeters,A. M. May,H. B. Bueno-de-Mesquita,F. J. B. van Duijnhoven,Göran Hallmans,Lars Weinehall,Jonas Manjer,Bo Hedblad,Eiliv Lund,Antonio Agudo,L. Arriola,Aurelio Barricarte,Carmen Navarro,Carlos Martinez,J. R. Quirós,Timothy J. Key,Sheila Bingham,Kay-Tee Khaw,Paolo Boffetta,Mazda Jenab,Pietro Ferrari,Elio Riboli +48 more
TL;DR: It is suggested that both general adiposity and abdominal adiposity are associated with the risk of death and support the use of waist circumference or waist-to-hip ratio in addition to BMI in assessing therisk of death.
Journal ArticleDOI
Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents
Emanuele Di Angelantonio,Shilpa N Bhupathiraju,David Wormser,Pei Gao,Pei Gao,Stephen Kaptoge,Amy Berrington de Gonzalez,Benjamin J Cairns,Rachel R. Huxley,Chandra L. Jackson,Grace Joshy,Sarah Lewington,JoAnn E. Manson,Neil Murphy,Alpa V. Patel,Jonathan M. Samet,Mark Woodward,Mark Woodward,Mark Woodward,Wei Zheng,Maigen Zhou,Narinder Bansal,Aurelio Barricarte,Brian D. Carter,James R. Cerhan,Rory Collins,George Davey Smith,Xianghua Fang,Oscar H. Franco,Jane Green,Jim Halsey,Janet S. Hildebrand,Keum Ji Jung,Rosemary J. Korda,Dale McLerran,Steven C. Moore,Linda M. O’Keeffe,Ellie Paige,Anna Ramond,Gillian K Reeves,Betsy Rolland,Carlotta Sacerdote,Naveed Sattar,Eleni Sofianopoulou,June Stevens,Michael J. Thun,Hirotsugu Ueshima,Ling Yang,Young Duk Yun,Peter Willeit,Peter Willeit,Emily Banks,Valerie Beral,Zhengming Chen,Susan M. Gapstur,Marc J. Gunter,Patricia Hartge,Sun Ha Jee,Tai Hing Lam,Richard Peto,John D. Potter,Walter C. Willett,Simon G. Thompson,John Danesh,Frank B. Hu +64 more
TL;DR: The associations of both overweight and obesity with higher all-cause mortality were broadly consistent in four continents and supports strategies to combat the entire spectrum of excess adiposity in many populations.
Journal ArticleDOI
Critical review: vegetables and fruit in the prevention of chronic diseases
Heiner Boeing,Angela Bechthold,Achim Bub,Sabine Ellinger,Dirk Haller,Anja Kroke,Eva Leschik-Bonnet,Manfred J. Müller,H Oberritter,Matthias B. Schulze,Peter Stehle,Bernhard Watzl +11 more
TL;DR: This critical review on the associations between the intake of vegetables and fruit and the risk of several chronic diseases shows that a high daily intake of these foods promotes health.
Journal ArticleDOI
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study
Sheila Bingham,Nicholas E. Day,Robert Luben,Pietro Ferrari,Nadia Slimani,Teresa Norat,Françoise Clavel-Chapelon,Emmanuelle Kesse,Alexandra Nieters,Heiner Boeing,Anne Tjϕnneland,Kim Overvad,Carmen Martinez,Miren Dorronsoro,Carlos A. González,Timothy J. Key,Antonia Trichopoulou,Androniki Naska,Paolo Vineis,Rosario Tumino,Vittorio Krogh,H. Bas Bueno-de-Mesquita,Petra H.M. Peeters,Göran Berglund,Göran Hallmans,Eiliv Lund,Guri Skeie,Rudolf Kaaks,Elio Riboli +28 more
TL;DR: Dietary fibre in foods was inversely related to incidence of large bowel cancer, with the protective effect being greatest for the left side of the colon, and least for the rectum.
References
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Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices
Bruce K. Armstrong,Richard Doll +1 more
TL;DR: Dietary variables were strongly correlated with several types of cancer, particularly meat consumption with cancer of the colon and fat consumption with cancers of the breast and corpus uteri, suggesting a possible role for dietary factors in modifying the development of cancer at a number of other sites.
Journal ArticleDOI
The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition.
Elio Riboli,Rudolf Kaaks +1 more
TL;DR: EPIC is a multi-centre prospective cohort study designed to investigate the relation between diet, nutritional and metabolic characteristics, various lifestyle factors and the risk of cancer in middle-aged men and women.
Journal Article
EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer.
Nicholas E. Day,Suzy Oakes,Robert Luben,Kay-Tee Khaw,Sheila Bingham,Ailsa A Welch,NJ Wareham +6 more
Journal ArticleDOI
Comparison of dietary assessment methods in nutritional epidemiology: weighed records v . 24 h recalls, food-frequency questionnaires and estimated-diet records
Sheila Bingham,Caroline Gill,Ailsa A Welch,K. Day,Aedin Cassidy,Kay-Tee Khaw,M. J. Sneyd,Timothy J. Key,L. Roe,Nicholas E. Day +9 more
TL;DR: Comparisons between the average of the 16 d weighed records and the first presentation of each method indicated that food-frequency questionnaires were not appreciably better at placing individuals in the distribution of habitual diet than 24 h recalls, due partly to inaccuracies in the estimation of frequency of food consumption.
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