European prospective investigation into cancer and nutrition (EPIC): study populations and data collection
Elio Riboli,Kelly J. Hunt,Nadia Slimani,Pietro Ferrari,Teresa Norat,Michael T. Fahey,Charrondière Ur,Bertrand Hémon,Corinne Casagrande,Jérôme Vignat,Kim Overvad,Anne Tjønneland,Françoise Clavel-Chapelon,Anne C. M. Thiébaut,Jürgen Wahrendorf,Heiner Boeing,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Antonia Trichopoulou,Paolo Vineis,Domenico Palli,H. B. Bueno-De-Mesquita,Petra H.M. Peeters,Eiliv Lund,Dagrun Engeset,Carlos A. González,Aurelio Barricarte,Göran Berglund,Göran Hallmans,Nicholas E. Day,Timothy J. Key,Rudolf Kaaks,R. Saracci +32 more
TLDR
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.Abstract:
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrollment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.read more
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A candidate gene approach to searching for low-penetrance breast and prostate cancer genes.
David J. Hunter,Elio Riboli,Christopher A. Haiman,Demetrius Albanes,David Altshuler,Stephen J. Chanock,R B Haynes,Brian E. Henderson,Rudolf Kaaks,Daniel O. Stram,Gilles Thomas,Michael J. Thun,Hélène Blanché,Julie E. Buring,N P Burtt,Eugenia E. Calle,Howard M. Cann,F Canzian,Yen-Ching Chen,Graham A. Colditz,David G. Cox,Alison M. Dunning,Heather Spencer Feigelson,Matthew L. Freedman,John Michael Gaziano,Edward Giovannucci,Susan E. Hankinson,Joel N. Hirschhorn,Robert N. Hoover,Timothy J. Key,Laurence N. Kolonel,Peter Kraft,Loic Le Marchand,Simin Liu,Jing Ma,Sandra L. Melnick,Paul D.P. Pharaoh,Malcolm Cecil Pike,Carlos J. Rodriguez,Veronica Wendy Setiawan,Meir J. Stampfer,E Trapido,Ruth C. Travis,Jarmo Virtamo,Sholom Wacholder,Walter C. Willett +45 more
TL;DR: The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers ?
Journal ArticleDOI
A metabolomic study of biomarkers of meat and fish intake.
William Cheung,Pekka Keski-Rahkonen,Nada Assi,Pietro Ferrari,Heinz Freisling,Sabina Rinaldi,Nadia Slimani,Raul Zamora-Ros,Milena Rundle,Gary Frost,Helena Gibbons,Eibhlin Carr,Lorraine Brennan,Amanda J. Cross,Valeria Pala,Salvatore Panico,Carlotta Sacerdote,Domenico Palli,Rosario Tumino,Tilman Kühn,Rudolf Kaaks,Heiner Boeing,Anna Floegel,Francesca Mancini,Francesca Mancini,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Laura Baglietto,Laura Baglietto,Antonia Trichopoulou,Androniki Naska,Philippos Orfanos,Augustin Scalbert +32 more
TL;DR: The meat and fish biomarkers identified in this work may be used to study associations between meat andFish intake and disease risk in epidemiologic studies.
Journal ArticleDOI
Environmental immune disruptors, inflammation and cancer risk.
Patricia A. Thompson,Mahin Khatami,Carolyn J. Baglole,Jun Sun,Shelley A. Harris,Eun-Yi Moon,Fahd Al-Mulla,Rabeah Al-Temaimi,Dustin G. Brown,Annamaria Colacci,Chiara Mondello,Jayadev Raju,Elizabeth P. Ryan,Jordan Woodrick,A. Ivana Scovassi,Neetu Singh,Monica Vaccari,Rabindra Roy,Stefano Forte,Lorenzo Memeo,Hosni Salem,Amedeo Amedei,Roslida Abd Hamid,Leroy Lowe,Tiziana Guarnieri,William H. Bisson +25 more
TL;DR: The role that the innate immune cells of inflammatory responses play in tumorigenesis is reviewed and the evidence linking environmental toxicant exposures with perturbation in the balance between pro- and anti-inflammatory responses is reviewed.
Journal ArticleDOI
Mediterranean diet and colorectal cancer risk: results from a European cohort
Christina Bamia,Pagona Lagiou,Pagona Lagiou,Pagona Lagiou,Genevieve Buckland,Sara Grioni,Claudia Agnoli,Aliki J. Taylor,Christina C. Dahm,Kim Overvad,Anja Olsen,Anne Tjønneland,Vanessa Cottet,Vanessa Cottet,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Sophie Morois,Sophie Morois,Verena A. Grote,Birgit Teucher,Heiner Boeing,Brian Buijsse,Dimitrios Trichopoulos,Dimitrios Trichopoulos,George Adarakis,Rosario Tumino,Alessio Naccarati,Salvatore Panico,Domenico Palli,H. Bas Bueno-de-Mesquita,Fränzel J.B. Van Duijnhoven,Petra H.M. Peeters,Petra H.M. Peeters,Dagrun Engeset,Guri Skeie,Eiliv Lund,María José Sánchez,Aurelio Barricarte,José María Huerta,J. Ramón Quirós,Miren Dorronsoro,Ingrid Ljuslinder,Richard Palmqvist,Isabel Drake,Timothy J. Key,Kay-Tee Khaw,Nicholas J. Wareham,Isabelle Romieu,Veronika Fedirko,Mazda Jenab,Dora Romaguera,Teresa Norat,Antonia Trichopoulou,Antonia Trichopoulou +53 more
TL;DR: It is suggested that following a Mediterranean diet may have a modest beneficial effect on CRC risk, mainly manifested for colon cancer risk and their magnitude was not altered when alcohol was excluded from MMDS.
Journal ArticleDOI
Long-term weight change and breast cancer risk: the European prospective investigation into cancer and nutrition (EPIC).
Petra H. Lahmann,M. Schulz,Kurt Hoffmann,Heiner Boeing,Anne Tjønneland,Anja Olsen,Kim Overvad,Timothy J. Key,Naomi E. Allen,Kay-Tee Khaw,Sheila Bingham,Göran Berglund,Elisabet Wirfält,Franco Berrino,Vittorio Krogh,Antonia Trichopoulou,Pagona Lagiou,Dimitrios Trichopoulos,Rudolf Kaaks,Elio Riboli +19 more
TL;DR: It is suggested that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones, although, overall, these women experienced a much higher risk of Breast cancer compared with nonusers.
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