European prospective investigation into cancer and nutrition (EPIC): study populations and data collection
Elio Riboli,Kelly J. Hunt,Nadia Slimani,Pietro Ferrari,Teresa Norat,Michael T. Fahey,Charrondière Ur,Bertrand Hémon,Corinne Casagrande,Jérôme Vignat,Kim Overvad,Anne Tjønneland,Françoise Clavel-Chapelon,Anne C. M. Thiébaut,Jürgen Wahrendorf,Heiner Boeing,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Antonia Trichopoulou,Paolo Vineis,Domenico Palli,H. B. Bueno-De-Mesquita,Petra H.M. Peeters,Eiliv Lund,Dagrun Engeset,Carlos A. González,Aurelio Barricarte,Göran Berglund,Göran Hallmans,Nicholas E. Day,Timothy J. Key,Rudolf Kaaks,R. Saracci +32 more
TLDR
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.Abstract:
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrollment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.read more
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Validity of self-reported prevalent cases of stroke and acute myocardial infarction in the Spanish cohort of the EPIC study
Mónica Machón,Larraitz Arriola,Nerea Larrañaga,Pilar Amiano,Concepción Moreno-Iribas,Antonio Agudo,Eva Ardanaz,Aurelio Barricarte,Genevieve Buckland,Ma Dolores Chirlaque,Diana Gavrila,José María Huerta,Carmen Martinez,Esther Molina,Carmen Navarro,José Ramón Quirós,Laudina Rodríguez,María José Sánchez,Carlos A. González,Miren Dorronsoro +19 more
TL;DR: Self-reported information on stroke and AMI included in the EPIC questionnaire is a valid instrument for the assessment of AMI disease but should be used with caution in stroke.
Journal ArticleDOI
Life Satisfaction and Risk of Chronic Diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany Study
TL;DR: The results of this study suggest that reduced life satisfaction is related to the development of chronic diseases—particularly in women and partly mediated by established risk factors.
Journal ArticleDOI
Genetic Variation in the HSD17B1 Gene and Risk of Prostate Cancer
Peter Kraft,Paul D.P. Pharoah,Stephen J. Chanock,Demetrius Albanes,Laurence N. Kolonel,Richard B. Hayes,David Altshuler,Gerald L. Andriole,Christine D. Berg,Heiner Boeing,Noël P. Burtt,Bas Bueno-de-Mesquita,Eugenia E. Calle,Howard M. Cann,Federico Canzian,Yen-Ching Chen,David Crawford,Alison M. Dunning,Heather Spencer Feigelson,Matthew L. Freedman,John Michael Gaziano,Edward Giovannucci,Carlos A. González,Christopher A. Haiman,Göran Hallmans,Brian E. Henderson,Joel N. Hirschhorn,David J. Hunter,Rudolf Kaaks,Timothy J. Key,Loic Le Marchand,Jing Ma,Kim Overvad,Domenico Palli,Malcolm C. Pike,Elio Riboli,Carmen Rodriguez,Wendy V Setiawan,Meir J. Stampfer,Daniel O. Stram,Gilles Thomas,Michael J. Thun,Ruth C. Travis,Antonia Trichopoulou,Jarmo Virtamo,Sholom Wacholder +45 more
TL;DR: The results of a comprehensive study of the association between HSD17B1 and prostate cancer by the Breast and Prostate Cancer Cohort Consortium, a large collaborative study as mentioned in this paper showed no evidence that the germline variants in htSNPs characterized by these haplotypes do not substantially influence the risk of prostate cancer in U.S. and European whites.
Journal ArticleDOI
Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study
Carlos González,Noémie Travier,Leila Lujan-Barroso,Xavier Castellsagué,F. Xavier Bosch,Esther Roura,H. Bas Bueno-de-Mesquita,Domenico Palli,Heiner Boeing,Valeria Pala,Carlotta Sacerdote,Rosario Tumino,Salvatore Panico,Jonas Manjer,Joakim Dillner,Göran Hallmans,Lennart Kjellberg,María José Sánchez,Jone M. Altzibar,Aurelio Barricarte,Carmen Navarro,Laudina Rodríguez,Naomi E. Allen,Timothy J. Key,Rudolf Kaaks,Sabine Rohrmann,Kim Overvad,Anja Olsen,Anne Tjønneland,Christian Munk,Susanne K. Kjaer,Petra H.M. Peeters,Fränzel J.B. Van Duijnhoven,Françoise Clavel-Chapelon,Marie-Christine Boutron-Ruault,Antonia Trichopoulou,Vasiliki Benetou,Androniki Naska,Eiliv Lund,Dagrun Engeset,Guri Skeie,Silvia Franceschi,Nadia Slimani,Sabina Rinaldi,Elio Riboli +44 more
TL;DR: A possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases are suggested.
Journal ArticleDOI
Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study.
Heinz Freisling,Hwayoung Noh,Nadia Slimani,Veronique Chajes,Anne M. May,Petra H.M. Peeters,Petra H.M. Peeters,Elisabete Weiderpass,Amanda J. Cross,Guri Skeie,Mazda Jenab,Francesca Mancini,Francesca Mancini,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Guy Fagherazzi,Guy Fagherazzi,Verena Katzke,Tilman Kühn,Annika Steffen,Heiner Boeing,Anne Tjønneland,Cecilie Kyrø,Camilla Plambeck Hansen,Kim Overvad,Eric J. Duell,Daniel Redondo-Sánchez,Pilar Amiano,Carmen Navarro,Aurelio Barricarte,Aurora Perez-Cornago,Konstantinos K. Tsilidis,Konstantinos K. Tsilidis,Dagfinn Aune,Heather Ward,Antonia Trichopoulou,Androniki Naska,Philippos Orfanos,Giovanna Masala,Claudia Agnoli,Franco Berrino,Rosario Tumino,Carlotta Sacerdote,Amalia Mattiello,H. Bas Bueno-de-Mesquita,H. Bas Bueno-de-Mesquita,Ulrika Ericson,Emily Sonestedt,Anna Winkvist,Tonje Braaten,Isabelle Romieu,Joan Sabaté +51 more
TL;DR: Higher intake of nuts is associated with reduced weight gain and a lower risk of becoming overweight or obese, according to baseline body mass index.
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