European prospective investigation into cancer and nutrition (EPIC): study populations and data collection
Elio Riboli,Kelly J. Hunt,Nadia Slimani,Pietro Ferrari,Teresa Norat,Michael T. Fahey,Charrondière Ur,Bertrand Hémon,Corinne Casagrande,Jérôme Vignat,Kim Overvad,Anne Tjønneland,Françoise Clavel-Chapelon,Anne C. M. Thiébaut,Jürgen Wahrendorf,Heiner Boeing,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Antonia Trichopoulou,Paolo Vineis,Domenico Palli,H. B. Bueno-De-Mesquita,Petra H.M. Peeters,Eiliv Lund,Dagrun Engeset,Carlos A. González,Aurelio Barricarte,Göran Berglund,Göran Hallmans,Nicholas E. Day,Timothy J. Key,Rudolf Kaaks,R. Saracci +32 more
TLDR
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.Abstract:
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrollment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.read more
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Vegetable and fruit consumption and the risk of hormone receptor-defined breast cancer in the EPIC cohort.
Marleen J. Emaus,Petra H.M. Peeters,Petra H.M. Peeters,Marije F. Bakker,Kim Overvad,Anne Tjønneland,Anja Olsen,Isabelle Romieu,Pietro Ferrari,Laure Dossus,Laure Dossus,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Laura Baglietto,Renée T. Fortner,Rudolf Kaaks,Heiner Boeing,Antonia Trichopoulou,Antonia Trichopoulou,Pagona Lagiou,Pagona Lagiou,Pagona Lagiou,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Giovanna Masala,Valeria Pala,Salvatore Panico,Rosario Tumino,Silvia Polidoro,Guri Skeie,Eiliv Lund,Elisabete Weiderpass,J. Ramón Quirós,Noémie Travier,María José Sánchez,María Dolores Chirlaque,Eva Ardanaz,Miren Dorronsoro,Anna Winkvist,Anna Winkvist,Maria Wennberg,H. Bas Bueno-de-Mesquita,Kay-Tee Khaw,Ruth C. Travis,Timothy J. Key,Dagfinn Aune,Marc J. Gunter,Elio Riboli,Carla H. van Gils +48 more
TL;DR: Evidence is provided that a high vegetable intake is associated with lower (mainly hormone receptor-negative) breast cancer risk and the test for heterogeneity by hormone receptor status was not significant.
Journal ArticleDOI
Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density
Martijn Verheus,James McKay,Rudolf Kaaks,Federico Canzian,Carine Biessy,Mattias Johansson,Diederick E. Grobbee,Petra H.M. Peeters,Carla H. van Gils +8 more
TL;DR: Common genetic variation in the IGF-1 gene is related to circulating levels of IGF-I, but the relationship with breast density is indecisive.
Journal ArticleDOI
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
Shu Chun Chuang,Rachael Z. Stolzenberg-Solomon,Per Magne Ueland,Stein Emil Vollset,Stein Emil Vollset,Øivind Midttun,Anja Olsen,Anne Tjønneland,Kim Overvad,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Sophie Morois,Sophie Morois,F. Clavel-Chapelon,F. Clavel-Chapelon,Birgit Teucher,Rudolf Kaaks,Cornelia Weikert,Heiner Boeing,Antonia Trichopoulou,Vassiliki Benetou,Androniki Naska,Mazda Jenab,Nadia Slimani,Isabelle Romieu,Dominique S. Michaud,Dominique S. Michaud,Domenico Palli,Sabina Sieri,Salvatore Panico,Carlotta Sacerdote,Rosario Tumino,Guri Skeie,Eric J. Duell,Laudina Rodríguez,Esther Molina-Montes,José María Huerta,Nerea Larrañaga,Aurelio Barricarte Gurrea,Dorthe Johansen,Jonas Manjer,Weimin Ye,Weimin Ye,Malin Sund,Petra H.M. Peeters,Petra H.M. Peeters,Suzanne M. Jeurnink,Nicholas J. Wareham,Kay-Tee Khaw,Francesca L. Crowe,Elio Riboli,Bas Bueno-de-Mesquita,Paolo Vineis +52 more
TL;DR: A U-shaped association between plasma folate and pancreatic cancer risk is observed and may be sex dependent and may differ by time of follow-up, however, the mechanisms behind the observed associations warrant further investigation.
Journal ArticleDOI
No relationship between circulating levels of sex steroids and mammographic breast density: the Prospect-EPIC cohort
Martijn Verheus,Petra H.M. Peeters,Paulus A.H. van Noord,Yvonne T. van der Schouw,Diederick E. Grobbee,Carla H. van Gils +5 more
TL;DR: The hypothesis that sex steroids increase postmenopausal breast cancer risk via an increase in breast density is supported, but both oestrogens and testosterone were inversely related with percent breast density, but these relationships disappeared after adjustment for BMI.
Journal ArticleDOI
Epigenetic Biomarkers in Colorectal Cancer
Mukesh Verma,Vineet Kumar +1 more
TL;DR: Challenges in the understanding of CRC development and gaps in knowledge are discussed andEpigenetic biomarkers have potential in CRC diagnosis and in measuring response to therapy.
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TL;DR: EPIC is a multi-centre prospective cohort study designed to investigate the relation between diet, nutritional and metabolic characteristics, various lifestyle factors and the risk of cancer in middle-aged men and women.
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