European prospective investigation into cancer and nutrition (EPIC): study populations and data collection
Elio Riboli,Kelly J. Hunt,Nadia Slimani,Pietro Ferrari,Teresa Norat,Michael T. Fahey,Charrondière Ur,Bertrand Hémon,Corinne Casagrande,Jérôme Vignat,Kim Overvad,Anne Tjønneland,Françoise Clavel-Chapelon,Anne C. M. Thiébaut,Jürgen Wahrendorf,Heiner Boeing,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Antonia Trichopoulou,Paolo Vineis,Domenico Palli,H. B. Bueno-De-Mesquita,Petra H.M. Peeters,Eiliv Lund,Dagrun Engeset,Carlos A. González,Aurelio Barricarte,Göran Berglund,Göran Hallmans,Nicholas E. Day,Timothy J. Key,Rudolf Kaaks,R. Saracci +32 more
TLDR
The present paper provides a description of theEPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.Abstract:
The European Prospective Investigation into Cancer and Nutrition (EPIC) is an ongoing multi-centre prospective cohort study designed to investigate the relationship between nutrition and cancer, with the potential for studying other diseases as well. The study currently includes 519 978 participants (366 521 women and 153 457 men, mostly aged 35-70 years) in 23 centres located in 10 European countries, to be followed for cancer incidence and cause-specific mortality for several decades. At enrollment, which took place between 1992 and 2000 at each of the different centres, information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire addressing usual diet. Anthropometric measurements were performed and blood samples taken, from which plasma, serum, red cells and buffy coat fractions were separated and aliquoted for long-term storage, mostly in liquid nitrogen. To calibrate dietary measurements, a standardised, computer-assisted 24-hour dietary recall was implemented at each centre on stratified random samples of the participants, for a total of 36 900 subjects. EPIC represents the largest single resource available today world-wide for prospective investigations on the aetiology of cancers (and other diseases) that can integrate questionnaire data on lifestyle and diet, biomarkers of diet and of endogenous metabolism (e.g. hormones and growth factors) and genetic polymorphisms. First results of case-control studies nested within the cohort are expected early in 2003. The present paper provides a description of the EPIC study, with the aim of simplifying reference to it in future papers reporting substantive or methodological studies carried out in the EPIC cohort.read more
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Mortality in British vegetarians: review and preliminary results from EPIC-Oxford
Timothy J. Key,Paul N. Appleby,Gwyneth K. Davey,Naomi E. Allen,Elizabeth A Spencer,Ruth C. Travis +5 more
TL;DR: The mortality of both the vegetarians and the nonvegetarians in these studies is low compared with national rates, and the nonsignificant reduction in mortality from ischemic heart disease among vegetarians was compatible with the significant reduction previously reported in a pooled analysis of mortality in Western vegetarians.
Journal ArticleDOI
Fruit and vegetable consumption and prospective weight change in participants of the European Prospective Investigation into Cancer and Nutrition–Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home, and Obesity study
Anne-Claire Vergnaud,Teresa Norat,Dora Romaguera,Traci Mouw,Anne M. May,Isabelle Romieu,Heinz Freisling,Nadia Slimani,Marie-Christine Boutron-Ruault,Marie-Christine Boutron-Ruault,Françoise Clavel-Chapelon,Françoise Clavel-Chapelon,Sophie Morois,Sophie Morois,Rudolf Kaaks,Birgit Teucher,Heiner Boeing,Brian Buijsse,Anne Tjønneland,Jytte Halkjær,Kim Overvad,Kim Overvad,Marianne Uhre Jakobsen,Marianne Uhre Jakobsen,Laudina Rodríguez,Antonio Agudo,María José Sánchez,Pilar Amiano,José María Huerta,Aurelio Barricarte Gurrea,Nicholas J. Wareham,Kay-Tee Khaw,Francesca L. Crowe,Philippos Orfanos,Androniki Naska,Antonia Trichopoulou,Giovanna Masala,Valeria Pala,Rosario Tumino,Carlotta Sacerdote,Amalia Mattiello,H. Bas Bueno-de-Mesquita,Fränzel J.B. Van Duijnhoven,Isabel Drake,Elisabet Wirfält,Ingegerd Johansson,Göran Hallmans,Dagrun Engeset,Tonje Braaten,Christine L. Parr,Andreani D. Odysseos,Elio Riboli,Petra H.M. Peeters,Petra H.M. Peeters +53 more
TL;DR: Higher baseline fruit and vegetable intakes, while maintaining total energy intakes constant, did not substantially influence midterm weight change overall but could help to reduce risk of weight gain in persons who stop smoking.
Journal ArticleDOI
Dual Association of β-Carotene With Risk of Tobacco-Related Cancers in a Cohort of French Women
TL;DR: Beta-carotene intake was inversely associated with risk of tobacco-related cancers among nonsmokers with a statistically significant dose-dependent relationship, whereas high beta-carotinine intake was directly associated withrisk among smokers.
Journal ArticleDOI
Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition
Petra H. Lahmann,Anne E. Cust,Anne E. Cust,Christine M. Friedenreich,Mandy Schulz,Annekatrin Lukanova,Rudolf Kaaks,Eva Lundin,Anne Tjønneland,Jytte Halkjær,Marianne Tang Severinsen,Kim Overvad,Kim Overvad,Agnès Fournier,Nathalie Chabbert-Buffet,Françoise Clavel-Chapelon,Laure Dossus,Tobias Pischon,Heiner Boeing,Antonia Trichopoulou,Pagona Lagiou,Androniki Naska,Domenico Palli,Sara Grioni,Amalia Mattiello,Rosario Tumino,Carlotta Sacerdote,Maria Luisa Redondo,Paula Jakszyn,María José Sánchez,María José Tormo,Eva Ardanaz,Larraitz Arriola,Jonas Manjer,Karin Jirström,H. Bas Bueno-de-Mesquita,Anne M. May,Anne M. May,Petra H.M. Peeters,N. Charlotte Onland-Moret,Sheila Bingham,Kay-Tee Khaw,Naomi E. Allen,Elizabeth A Spencer,Sabina Rinaldi,Nadia Slimani,Veronique Chajes,Dominique S. Michaud,Teresa Norat,Elio Riboli +49 more
TL;DR: Evidence is provided that obesity is an important modifiable risk factor for epithelial ovarian cancer, particularly among postmenopausal women, and for all women combined.
Intake of total, animal and plant protein and subsequent changes in weight or waist circumference in European men and women: the Diogenes project Long-term experience with kidney transplantation from hepatitis C-positive donors into hepatitis C-positi
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TL;DR: EPIC is a multi-centre prospective cohort study designed to investigate the relation between diet, nutritional and metabolic characteristics, various lifestyle factors and the risk of cancer in middle-aged men and women.
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