Christina Schüler

TL;DR: Red, single-wavelength GECIs, “RCaMPs,” engineered from circular permutation of the thermostable red fluorescent protein mRuby are described and 2-color calcium imaging is demonstrated both within the same cell (registering mitochondrial and somatic [Ca2+]) and between two populations of cells: neurons and astrocytes.

TL;DR: It is demonstrated here that RIS also functions as a locomotion stop neuron, possibly enabling sensory integration and decision making, and exemplifies dual use of one cell across development in a compact nervous system.

TL;DR: This work evaluated rhodopsin tools for voltage imaging in muscles and neurons of Caenorhabditis elegans, a prime animal model in neuro- and cell biology, showing robust performance and the ability to characterize genetic mutants.

TL;DR: A model may allow screening of drug candidates affecting specific VGCCs mutations, and permit to better understand the effects of distinct mutations on a macroscopic level, to enable drug development for distinct arrhythmias.

TL;DR: The ‘worm arrhythmia’ of Caenorhabditis elegans is reversed by the benzothiazepine S107, establishing the nematode pharynx for studying specific CPVT mutations and for drug screening.