M
Matthias Prigge
Researcher at Weizmann Institute of Science
Publications - 24
Citations - 7079
Matthias Prigge is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Channelrhodopsin & Optogenetics. The author has an hindex of 18, co-authored 19 publications receiving 6131 citations. Previous affiliations of Matthias Prigge include Humboldt State University & Humboldt University of Berlin.
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Journal ArticleDOI
Neocortical excitation/inhibition balance in information processing and social dysfunction
Ofer Yizhar,Ofer Yizhar,Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Daniel J. O’Shea,Vikaas S. Sohal,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +17 more
TL;DR: In this article, the authors design and use several optogenetic tools to causally investigate the cellular E/I balance hypothesis in freely moving mammals, and explore the associated circuit physiology.
Neocortical excitation/inhibition balance in information processing and social
Lief E. Fenno,Matthias Prigge,Franziska Schneider,Thomas J. Davidson,Vikaas S. Sohal,Inbal Goshen,Joel Finkelstein,Jeanne T. Paz,Katja Stehfest,Roman Fudim,Charu Ramakrishnan,John R. Huguenard,Peter Hegemann,Karl Deisseroth +13 more
TL;DR: Elevation, but not reduction, of cellular E/I balance within the mouse medial prefrontal cortex was found to elicit a profound impairment in cellular information processing, associated with specific behavioural impairments and increased high-frequency power in the 30–80 Hz range, which have both been observed in clinical conditions in humans.
Journal ArticleDOI
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.
Jasper Akerboom,Nicole Carreras Calderón,Nicole Carreras Calderón,Nicole Carreras Calderón,Lin Tian,Lin Tian,Sebastian Wabnig,Matthias Prigge,Johan Tolö,Andrew Gordus,Michael B. Orger,Michael B. Orger,Kristen E. Severi,John J. Macklin,Ronak Patel,Stefan R. Pulver,Trevor J. Wardill,Trevor J. Wardill,Elisabeth Fischer,Christina Schüler,Tsai Wen Chen,Karen S. Sarkisyan,Jonathan S. Marvin,Cornelia I. Bargmann,Douglas S. Kim,Sebastian Kügler,Leon Lagnado,Peter Hegemann,Alexander Gottschalk,Eric R. Schreiter,Eric R. Schreiter,Loren L. Looger +31 more
TL;DR: Red, single-wavelength GECIs, “RCaMPs,” engineered from circular permutation of the thermostable red fluorescent protein mRuby are described and 2-color calcium imaging is demonstrated both within the same cell (registering mitochondrial and somatic [Ca2+]) and between two populations of cells: neurons and astrocytes.
Journal ArticleDOI
Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri
Feng Zhang,Matthias Prigge,Florent Beyrière,Satoshi P. Tsunoda,Joanna Mattis,Ofer Yizhar,Peter Hegemann,Karl Deisseroth +7 more
TL;DR: A cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted ∼70 nm compared with ChR2 is described, thereby defining a functionally distinct third category of microbial rhodopin proteins.
Journal ArticleDOI
The Microbial Opsin Family of Optogenetic Tools
Feng Zhang,Johannes Vierock,Ofer Yizhar,Lief E. Fenno,Satoshi Tsunoda,Arash Kianianmomeni,Matthias Prigge,Andre Berndt,John C. Cushman,Juergen E. W. Polle,Jon K. Magnuson,Peter Hegemann,Karl Deisseroth +12 more
TL;DR: A Primer on these light-activated ion channels and pumps is provided, a group of opsins bridging prior categories are described, and the convergence of molecular engineering and genomic discovery for the utilization and understanding of these remarkable molecular machines are explored.