K
Kristen E. Severi
Researcher at New Jersey Institute of Technology
Publications - 15
Citations - 1443
Kristen E. Severi is an academic researcher from New Jersey Institute of Technology. The author has contributed to research in topics: Motor control & Optogenetics. The author has an hindex of 7, co-authored 15 publications receiving 1224 citations. Previous affiliations of Kristen E. Severi include Pierre-and-Marie-Curie University & Harvard University.
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Journal ArticleDOI
Genetically encoded calcium indicators for multi-color neural activity imaging and combination with optogenetics.
Jasper Akerboom,Nicole Carreras Calderón,Nicole Carreras Calderón,Nicole Carreras Calderón,Lin Tian,Lin Tian,Sebastian Wabnig,Matthias Prigge,Johan Tolö,Andrew Gordus,Michael B. Orger,Michael B. Orger,Kristen E. Severi,John J. Macklin,Ronak Patel,Stefan R. Pulver,Trevor J. Wardill,Trevor J. Wardill,Elisabeth Fischer,Christina Schüler,Tsai Wen Chen,Karen S. Sarkisyan,Jonathan S. Marvin,Cornelia I. Bargmann,Douglas S. Kim,Sebastian Kügler,Leon Lagnado,Peter Hegemann,Alexander Gottschalk,Eric R. Schreiter,Eric R. Schreiter,Loren L. Looger +31 more
TL;DR: Red, single-wavelength GECIs, “RCaMPs,” engineered from circular permutation of the thermostable red fluorescent protein mRuby are described and 2-color calcium imaging is demonstrated both within the same cell (registering mitochondrial and somatic [Ca2+]) and between two populations of cells: neurons and astrocytes.
Journal ArticleDOI
Control of visually guided behavior by distinct populations of spinal projection neurons.
TL;DR: A new behavioral assay was used to identify visual stimuli that specifically drive basic motor patterns in zebrafish and found that stimuli that drive distinct behaviors activated distinct subsets of projection neurons, consisting of just a few cells.
Journal ArticleDOI
Neural Control and Modulation of Swimming Speed in the Larval Zebrafish
Kristen E. Severi,Kristen E. Severi,Ruben Portugues,João C. Marques,Donald M. O'Malley,Michael B. Orger,Florian Engert +6 more
TL;DR: The activity of single identified neurons within the nMLF is correlated with locomotor kinematics, and modulates both the duration and oscillation frequency of tail movements, which helps build a better understanding of how the brain controls movement.
Journal ArticleDOI
ZebraZoom: an automated program for high-throughput behavioral analysis and categorization.
Olivier Mirat,Olivier Mirat,Jenna R. Sternberg,Jenna R. Sternberg,Kristen E. Severi,Claire Wyart +5 more
TL;DR: ZebraZoom, a program to automatically track larvae and identify maneuvers for many animals performing discrete movements, reached the level of precision found in manual analysis but accomplished tasks in a high-throughput format necessary for large screens.
Journal ArticleDOI
Optogenetics in a transparent animal: circuit function in the larval zebrafish.
TL;DR: In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system.