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Alessandro Olivi
Researcher at Agostino Gemelli University Polyclinic
Publications - 225
Citations - 19575
Alessandro Olivi is an academic researcher from Agostino Gemelli University Polyclinic. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 52, co-authored 163 publications receiving 17205 citations. Previous affiliations of Alessandro Olivi include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
D. Williams Parsons,Siân Jones,Xiaosong Zhang,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,I-Mei Siu,Gary L. Gallia,Alessandro Olivi,Roger E. McLendon,B.K. Ahmed Rasheed,Stephen T. Keir,Tatiana Nikolskaya,Yuri Nikolsky,Dana A. Busam,Hanna Tekleab,Luis A. Diaz,James Hartigan,Doug R. Smith,Robert L. Strausberg,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Hai Yan,Gregory J. Riggins,Darell D. Bigner,Rachel Karchin,Nick Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +32 more
TL;DR: Recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival.
Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Sara Grazia Maria Piccirillo,Brent A. Reynolds,N. Zanetti,Giuseppe Lamorte,Elena Binda,Giovanni Broggi,Henry Brem,Alessandro Olivi,Francesco DiMeco,Angelo L. Vescovi +9 more
TL;DR: Findings show that the BMP–BMPR signalling system—which controls the activity of normal brain stem cells—may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.
Journal ArticleDOI
Independent association of extent of resection with survival in patients with malignant brain astrocytoma: Clinical article
Matthew J. McGirt,Kaisorn L. Chaichana,Muraya Gathinji,Frank J. Attenello,Khoi D. Than,Alessandro Olivi,Jon D. Weingart,Henry Brem,Alf redo Quiñones-Hinojosa +8 more
TL;DR: In the authors' experience with both primary and secondary resection of malignant brain astrocytomas, increasing extent of resection was associated with improved survival independent of age, degree of disability, WHO grade, or subsequent treatment modalities used.
Journal ArticleDOI
Cyclopamine-mediated Hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma
Eli E. Bar,Aneeka Chaudhry,Alex Lin,Xing Fan,Karisa C. Schreck,William Matsui,Sara Grazia Maria Piccirillo,Angelo L. Vescovi,Francesco DiMeco,Alessandro Olivi,Charles G. Eberhart +10 more
TL;DR: Investigating whether Hedgehog blockade could target the stem‐like population in glioblastoma multiforme found that Gli1, a key Hedgehog pathway target, was highly expressed in 5 of 19 primary GBM and in 4 of 7 GBM cell lines, and Shh ligand was expressed in some primary tumors, and in GBM‐derived neurospheres, suggesting a potential mechanism for pathway activation.