H
Henry Brem
Researcher at Johns Hopkins University School of Medicine
Publications - 408
Citations - 32352
Henry Brem is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Glioma & Brain tumor. The author has an hindex of 84, co-authored 384 publications receiving 28435 citations. Previous affiliations of Henry Brem include Harvard University & Johns Hopkins University.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas
Henry Brem,Steven Piantadosi,Steven Piantadosi,Peter C. Burger,Michael D. Walker,Robert G. Selker,N. A. Vick,K Black,Michael B. Sisti,Steven Brem,G Mohr,P Muller,R Morawetz,S.C Schold +13 more
TL;DR: Interstitial chemotherapy delivered with polymers directly to brain tumours at the time of surgery seems to be a safe and effective treatment for recurrent malignant gliomas.
Journal ArticleDOI
Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
Sara Grazia Maria Piccirillo,Brent A. Reynolds,N. Zanetti,Giuseppe Lamorte,Elena Binda,Giovanni Broggi,Henry Brem,Alessandro Olivi,Francesco DiMeco,Angelo L. Vescovi +9 more
TL;DR: Findings show that the BMP–BMPR signalling system—which controls the activity of normal brain stem cells—may also act as a key inhibitory regulator of tumour-initiating, stem-like cells from GBMs and identify BMP4 as a novel, non-cytotoxic therapeutic effector, which may be used to prevent growth and recurrence of GBMs in humans.
Journal ArticleDOI
Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas.
Jing Zeng,Alfred P. See,Jillian Phallen,Christopher M. Jackson,Zineb Belcaid,Jacob Ruzevick,Nicholas M. Durham,Christian F. Meyer,Timothy J. Harris,Emilia Albesiano,Gustavo Pradilla,Eric C. Ford,John Wong,Hans J. Hammers,Dimitris Mathios,Betty Tyler,Henry Brem,Phuoc T. Tran,Drew M. Pardoll,Charles G. Drake,Michael Lim +20 more
TL;DR: The combination of PD-1 blockade and localized radiation therapy results in long-term survival in mice with orthotopic brain tumors, providing strong preclinical evidence to support combination trials in patients with GBM.
Journal ArticleDOI
Independent association of extent of resection with survival in patients with malignant brain astrocytoma: Clinical article
Matthew J. McGirt,Kaisorn L. Chaichana,Muraya Gathinji,Frank J. Attenello,Khoi D. Than,Alessandro Olivi,Jon D. Weingart,Henry Brem,Alf redo Quiñones-Hinojosa +8 more
TL;DR: In the authors' experience with both primary and secondary resection of malignant brain astrocytomas, increasing extent of resection was associated with improved survival independent of age, degree of disability, WHO grade, or subsequent treatment modalities used.