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C. Max Schmidt
Researcher at Indiana University – Purdue University Indianapolis
Publications - 79
Citations - 10108
C. Max Schmidt is an academic researcher from Indiana University – Purdue University Indianapolis. The author has contributed to research in topics: Pancreatic cancer & Intraductal papillary mucinous neoplasm. The author has an hindex of 29, co-authored 66 publications receiving 8782 citations. Previous affiliations of C. Max Schmidt include Purdue University & Indiana University.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Masao Tanaka,Carlos Fernandez-del Castillo,Volkan Adsay,Suresh T. Chari,Massimo Falconi,Jin-Young Jang,Wataru Kimura,Philippe Lévy,Martha B. Pitman,C. Max Schmidt,Michio Shimizu,Christopher L. Wolfgang,Koji Yamaguchi,Kenji Yamao +13 more
TL;DR: The present guidelines include recent information and recommendations based on the current understanding, and highlight issues that remain controversial and areas where further research is required.
Journal ArticleDOI
Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
Jian Wu,Hanno Matthaei,Anirban Maitra,Marco Dal Molin,Laura D. Wood,James R. Eshleman,Michael Goggins,Marcia I. Canto,Richard D. Schulick,Barish H. Edil,Christopher L. Wolfgang,Alison P. Klein,Luis A. Diaz,Peter J. Allen,C. Max Schmidt,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Bert Vogelstein +18 more
TL;DR: It is determined that the presence of mutations in two oncogenes can identify the cysts that are likely to progress to carcinoma and so are good candidates for surgical removal, and suggest that GNAS mutations can inform the diagnosis and management of patients with cystic pancreatic lesions.
Journal ArticleDOI
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways
Jian Wu,Yuchen Jiao,Marco Dal Molin,Anirban Maitra,Roeland F. de Wilde,Laura D. Wood,James R. Eshleman,Michael Goggins,Christopher L. Wolfgang,Marcia I. Canto,Richard D. Schulick,Barish H. Edil,Michael A. Choti,Volkan Adsay,David S. Klimstra,G. Johan A. Offerhaus,Alison P. Klein,Levy Kopelovich,Hannah Carter,Rachel Karchin,Peter J. Allen,C. Max Schmidt,Yoshiki Naito,Luis A. Diaz,Kenneth W. Kinzler,Nickolas Papadopoulos,Ralph H. Hruban,Bert Vogelstein +27 more
TL;DR: The preponderance of inactivating mutations in RNF43 unequivocally establish it as a suppressor of both IPMNs and MCNs, highlighting the essential role of ubiquitin ligases in these neoplasms and have important implications for the diagnosis and treatment of patients with cystic tumors.
Journal ArticleDOI
Pancreaticoduodenectomy: A 20-year experience in 516 patients
C. Max Schmidt,Emilie S. Powell,Constantin T. Yiannoutsos,Thomas J. Howard,Eric A. Wiebke,Chad A. Wiesenauer,Joel A. Baumgardner,Oscar W. Cummings,Lewis E. Jacobson,Thomas A. Broadie,David F. Canal,Robert J. Goulet,Eardie A. Curie,Higinia R. Cardenes,John M. Watkins,Patrick J. Loehrer,Keith D. Lillemoe,James A. Madura,Gerard V. Aranha,William W. Turner,Thomas A. Stellato,Richard A. Prinz,Sachinder Singh Hans,Arthur J. Donovan,Michael B. Farnell,Fabrizio Michelassi +25 more
TL;DR: Long-term survival in patients with periampullary adenocarcinoma can be predicted by preoperative laboratory values, intraoperative factors, and pathologic findings, and with careful patient selection, PD can be performed safely.