S
Seung-Mo Hong
Researcher at University of Ulsan
Publications - 383
Citations - 21628
Seung-Mo Hong is an academic researcher from University of Ulsan. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 53, co-authored 361 publications receiving 17907 citations. Previous affiliations of Seung-Mo Hong include University of Virginia Health System & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones,Xiaosong Zhang,D. Williams Parsons,D. Williams Parsons,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,Hirohiko Kamiyama,Antonio Jimeno,Seung-Mo Hong,Baojin Fu,Ming Tseh Lin,Eric S. Calhoun,Mihoko Kamiyama,Kimberly Walter,Tatiana Nikolskaya,Yuri Nikolsky,James Hartigan,Douglas Smith,Manuel Hidalgo,Steven D. Leach,Alison P. Klein,Elizabeth M. Jaffee,Michael Goggins,Anirban Maitra,Anirban Maitra,Christine A. Iacobuzio-Donahue,James R. Eshleman,Scott E. Kern,Ralph H. Hruban,Rachel Karchin,Nickolas Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +37 more
TL;DR: It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.
Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Mitsuro Kanda,Hanno Matthaei,Jian Wu,Seung-Mo Hong,Jun Yu,Michael Borges,Ralph H. Hruban,Anirban Maitra,Kenneth W. Kinzler,Bert Vogelstein,Michael Goggins +10 more
TL;DR: It is shown that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF, which could improve the understanding of the development and progression of these premalignant lesions.
Journal ArticleDOI
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Olca Basturk,Seung-Mo Hong,Laura D. Wood,N. Volkan Adsay,Jorge Albores-Saavedra,Andrew V. Biankin,Lodewijk A.A. Brosens,Noriyoshi Fukushima,Michael Goggins,Ralph H. Hruban,Yo Kato,David S. Klimstra,Günter Klöppel,Alyssa M. Krasinskas,Daniel S. Longnecker,Hanno Matthaei,G. Johan A. Offerhaus,Michio Shimizu,Kyoichi Takaori,Benoit Terris,Shinichi Yachida,Irene Esposito,Toru Furukawa +22 more
TL;DR: International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive carcinomas of the pancreas, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMN), mucinous cystic neoplasm, and other lesions.
Journal ArticleDOI
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
Christopher M. Heaphy,Andrea P. Subhawong,Seung-Mo Hong,Michael Goggins,Elizabeth A. Montgomery,Edward Gabrielson,George J. Netto,Jonathan I. Epstein,Tamara L. Lotan,William H. Westra,Ie Ming Shih,Christine A. Iacobuzio-Donahue,Anirban Maitra,Qing Kay Li,Charles G. Eberhart,Janis M. Taube,Dinesh Rakheja,Robert J. Kurman,Tzyy Choou Wu,Richard B.S. Roden,Pedram Argani,Angelo M. De Marzo,Luigi Terracciano,Michael Torbenson,Alan K. Meeker +24 more
TL;DR: The first report of ALT in carcinomas arising from the bladder, cervix, endometrium, esophagus, gallbladder, kidney, liver, and lung is reported, and ALT-positive cancers are predicted to be resistant to anti-telomerase therapies.