E
Emmanuel S. Antonarakis
Researcher at Johns Hopkins University
Publications - 546
Citations - 24015
Emmanuel S. Antonarakis is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Prostate cancer & Enzalutamide. The author has an hindex of 59, co-authored 443 publications receiving 18018 citations. Previous affiliations of Emmanuel S. Antonarakis include Bronglais General Hospital & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.
Emmanuel S. Antonarakis,Changxue Lu,Hao Wang,Brandon Luber,Mary Nakazawa,Jeffrey C. Roeser,Yan Chen,Tabrez A. Mohammad,Yi Chen,Helen L. Fedor,Tamara L. Lotan,Qizhi Zheng,Angelo M. De Marzo,John T. Isaacs,William B. Isaacs,Rosa Nadal,Channing J. Paller,Samuel R. Denmeade,Michael A. Carducci,Mario A. Eisenberger,Jun Luo +20 more
TL;DR: In this article, the androgen-receptor splice variant 7 (AR-V7) was found to be associated with resistance to enzalutamide and abiraterone.
Journal ArticleDOI
Prostate Cancer, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology
James L. Mohler,Emmanuel S. Antonarakis,Andrew J. Armstrong,Anthony V. D'Amico,Brian J. Davis,Tanya B. Dorff,James A. Eastham,Charles Arthur Enke,Thomas A. Farrington,Celestia S. Higano,Eric M. Horwitz,Michael E. Hurwitz,Joseph E. Ippolito,Christopher J. Kane,Michael Kuettel,Joshua M. Lang,Jesse K. McKenney,George J. Netto,David F. Penson,Elizabeth R. Plimack,Julio M. Pow-Sang,Thomas J. Pugh,Sylvia Richey,Mack Roach,Stan Rosenfeld,Edward M. Schaeffer,Ahmad Shabsigh,Eric J. Small,Daniel E. Spratt,Sandy Srinivas,Jonathan D. Tward,Dorothy A. Shead,Deborah A. Freedman-Cass +32 more
TL;DR: The NCCN Guidelines for Prostate Cancer include recommendations regarding diagnosis, risk stratification and workup, treatment options for localized disease, and management of recurrent and advanced disease for clinicians who treat patients with prostate cancer.
Journal ArticleDOI
Trial Design and Objectives for Castration-Resistant Prostate Cancer: Updated Recommendations From the Prostate Cancer Clinical Trials Working Group 3
Howard I. Scher,Michael J. Morris,Walter M. Stadler,Celestia S. Higano,Ethan Basch,Karim Fizazi,Emmanuel S. Antonarakis,Tomasz M. Beer,Michael A. Carducci,Kim N. Chi,Paul G. Corn,Johann S. de Bono,Robert Dreicer,Daniel J. George,Elisabeth I. Heath,Maha Hussain,Wm. Kevin Kelly,Glenn Liu,Christopher J. Logothetis,David M. Nanus,Mark N. Stein,Dana E. Rathkopf,Susan F. Slovin,Charles J. Ryan,Oliver Sartor,Eric J. Small,Matthew R. Smith,Cora N. Sternberg,Mary-Ellen Taplin,George Wilding,Peter S. Nelson,Lawrence H. Schwartz,Susan Halabi,Philip W. Kantoff,Andrew J. Armstrong +34 more
TL;DR: The concept of no longer clinically benefiting is introduced to underscore the distinction between first evidence of progression and the clinical need to terminate or change treatment, and the importance of documenting progression in existing lesions as distinct from the development of new lesions.
Journal ArticleDOI
Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial
Ryan Phillips,William Shi,Matthew P. Deek,Noura Radwan,Su Jin Lim,Emmanuel S. Antonarakis,Steven P. Rowe,Ashley E. Ross,Michael A. Gorin,Curtiland Deville,Stephen Greco,Hailun Wang,Samuel R. Denmeade,Channing J. Paller,Shirl Dipasquale,Theodore L. DeWeese,Danny Y. Song,Hao Wang,Michael A. Carducci,Kenneth J. Pienta,Martin G. Pomper,Adam P. Dicker,Mario A. Eisenberger,Ash A. Alizadeh,Maximilian Diehn,Phuoc T. Tran +25 more
TL;DR: This randomized clinical trial assesses whether treatment with stereotactic ablative radiotherapy vs observation improves oncologic outcomes in men with recurrent hormone-sensitive oligometastatic prostate cancer.