G
Gary L. Gallia
Researcher at Johns Hopkins University School of Medicine
Publications - 192
Citations - 15393
Gary L. Gallia is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 40, co-authored 171 publications receiving 13139 citations. Previous affiliations of Gary L. Gallia include Johns Hopkins University.
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Journal ArticleDOI
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
D. Williams Parsons,Siân Jones,Xiaosong Zhang,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,I-Mei Siu,Gary L. Gallia,Alessandro Olivi,Roger E. McLendon,B.K. Ahmed Rasheed,Stephen T. Keir,Tatiana Nikolskaya,Yuri Nikolsky,Dana A. Busam,Hanna Tekleab,Luis A. Diaz,James Hartigan,Doug R. Smith,Robert L. Strausberg,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Hai Yan,Gregory J. Riggins,Darell D. Bigner,Rachel Karchin,Nick Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +32 more
TL;DR: Recurrent mutations in the active site of isocitrate dehydrogenase 1 (IDH1) occurred in a large fraction of young patients and in most patients with secondary GBMs and were associated with an increase in overall survival.
Journal ArticleDOI
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Chetan Bettegowda,Chetan Bettegowda,Mark Sausen,Rebecca J. Leary,Isaac Kinde,Yuxuan Wang,Nishant Agrawal,Nishant Agrawal,Bjarne Bartlett,Bjarne Bartlett,Hao Wang,Brandon Luber,Rhoda M. Alani,Emmanuel S. Antonarakis,Nilofer S. Azad,Alberto Bardelli,Henry Brem,John L. Cameron,Clarence Lee,Leslie A. Fecher,Leslie A. Fecher,Gary L. Gallia,Peter Gibbs,Dung T. Le,Dung T. Le,Robert L. Giuntoli,Michael Goggins,Michael D. Hogarty,Matthias Holdhoff,Seung-Mo Hong,Seung-Mo Hong,Yuchen Jiao,Hartmut Juhl,Jenny J. Kim,Giulia Siravegna,Daniel A. Laheru,Calogero Lauricella,Michael Lim,Evan J. Lipson,Suely Kazue Nagahashi Marie,George J. Netto,Kelly S. Oliner,Alessandro Olivi,Louise Olsson,Gregory J. Riggins,Andrea Sartore-Bianchi,Kerstin Schmidt,le-Ming Shih,Sueli Mieko Oba-Shinjo,Salvatore Siena,Dan Theodorescu,Jeanne Tie,Timothy T. Harkins,Silvio Veronese,Tian Li Wang,Jon D. Weingart,Christopher L. Wolfgang,Laura D. Wood,Dongmei Xing,Ralph H. Hruban,Jian Wu,Peter J. Allen,C. Max Schmidt,Michael A. Choti,Victor E. Velculescu,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos,Luis A. Diaz,Luis A. Diaz +69 more
TL;DR: The ability of circulating tumor DNA (ctDNA) to detect tumors in 640 patients with various cancer types was evaluated and suggested that ctDNA is a broadly applicable, sensitive, and specific biomarker that can be used for a variety of clinical and research purposes.
Journal ArticleDOI
The Genetic Landscape of the Childhood Cancer Medulloblastoma
D. Williams Parsons,D. Williams Parsons,Meng Li,Xiaosong Zhang,Siân Jones,Rebecca J. Leary,Jimmy Lin,Simina M. Boca,Hannah Carter,Josue Samayoa,Chetan Bettegowda,Chetan Bettegowda,Gary L. Gallia,George I. Jallo,Zev A. Binder,Yuri Nikolsky,James Hartigan,Doug R. Smith,Daniela S. Gerhard,Daniel W. Fults,Scott R. VandenBerg,Mitchel S. Berger,Suely Kazue Nagahashi Marie,Sueli Mieko Oba Shinjo,Carlos Clara,Peter C. Phillips,Jane E. Minturn,Jaclyn A. Biegel,Alexander R. Judkins,Adam C. Resnick,Phillip B. Storm,Tom Curran,Yiping He,B.K. Ahmed Rasheed,Henry S. Friedman,Stephen T. Keir,Roger E. McLendon,Paul A. Northcott,Michael D. Taylor,Peter C. Burger,Gregory J. Riggins,Gregory J. Riggins,Rachel Karchin,Giovanni Parmigiani,Darell D. Bigner,Hai Yan,Nick Papadopoulos,Bert Vogelstein,Kenneth W. Kinzler,Victor E. Velculescu +49 more
TL;DR: Key differences between the genetic landscapes of adult and childhood cancers are demonstrated, dysregulation of developmental pathways as an important mechanism underlying MBs is highlighted, and a role for a specific type of histone methylation in human tumorigenesis is identified.
Journal ArticleDOI
Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma
Kaisorn L. Chaichana,Ignacio Jusué-Torres,Rodrigo Navarro-Ramirez,Shaan M. Raza,Maria Pascual-Gallego,Aly Ibrahim,Marta Hernandez-Hermann,Luis Gomez,Xiaobu Ye,Jon D. Weingart,Alessandro Olivi,Jaishri O. Blakeley,Gary L. Gallia,Michael Lim,Henry Brem,Alfredo Quiñones-Hinojosa +15 more
TL;DR: This study shows for the first time that both EOR and RV are significantly associated with survival and recurrence, where the thresholds are 70% and 5 cm(3), respectively.
Journal ArticleDOI
Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord
Yuxuan Wang,Simeon Springer,Ming Zhang,K. Wyatt McMahon,Isaac Kinde,Lisa Dobbyn,Janine Ptak,Henry Brem,Kaisorn L. Chaichana,Gary L. Gallia,Ziya L. Gokaslan,Mari L. Groves,George I. Jallo,Michael Lim,Alessandro Olivi,Alfredo Quiñones-Hinojosa,Daniele Rigamonti,Greg J. Riggins,Daniel M. Sciubba,Jon D. Weingart,Jean Paul Wolinsky,Xiaobu Ye,Sueli Mieko Oba-Shinjo,Suely Kazue Nagahashi Marie,Matthias Holdhoff,Nishant Agrawal,Luis A. Diaz,Nickolas Papadopoulos,Kenneth W. Kinzler,Bert Vogelstein,Chetan Bettegowda +30 more
TL;DR: It is shown here that primary CNS malignancies shed detectable levels of tumor DNA into the surrounding cerebrospinal fluid (CSF), which could serve as a sensitive and exquisitely specific marker for quantifying tumor burden without invasive biopsies.