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Chen Zhao
Researcher at Chongqing Medical University
Publications - 50
Citations - 2857
Chen Zhao is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Mesenchymal stem cell & Cellular differentiation. The author has an hindex of 24, co-authored 46 publications receiving 1795 citations. Previous affiliations of Chen Zhao include Third Military Medical University & Chongqing University.
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Journal ArticleDOI
Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs).
Junyi Liao,Qiang Wei,Yulong Zou,Jiaming Fan,Dongzhe Song,Jing Cui,Wenwen Zhang,Yunxiao Zhu,Chao Ma,Xue Hu,Xiangyang Qu,Liqun Chen,Xinyi Yu,Zhicai Zhang,Claire Q.F. Wang,Chen Zhao,Zongyue Zeng,Ruyi Zhang,Shujuan Yan,Tingting Wu,Xingye Wu,Yi Shu,Jiayan Lei,Yasha Li,Hue H. Luu,Michael J. Lee,Russell R. Reid,Guillermo A. Ameer,Jennifer Moriatis Wolf,Tong-Chuan He,Wei Huang +30 more
TL;DR: It’s conceivable that simultaneous activation of the BMP9 and Notch pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.
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Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine
Cody S. Lee,Elliot S. Bishop,Ruyi Zhang,Ruyi Zhang,Xinyi Yu,Xinyi Yu,Evan M. Farina,Shujuan Yan,Shujuan Yan,Chen Zhao,Chen Zhao,Zongyue Zeng,Zongyue Zeng,Yi Shu,Yi Shu,Xingye Wu,Xingye Wu,Jiayan Lei,Jiayan Lei,Yasha Li,Yasha Li,Wenwen Zhang,Wenwen Zhang,Chao Yang,Chao Yang,Ke Wu,Ke Wu,Ying Wu,Ying Wu,Sherwin S. W. Ho,Aravind Athiviraham,Michael J. Lee,Jennifer Moriatis Wolf,Russell R. Reid,Tong-Chuan He +34 more
TL;DR: It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.
Journal ArticleDOI
Wnt signaling in bone formation and its therapeutic potential for bone diseases
Jeong Hwan Kim,Xing Liu,Jinhua Wang,Xiang Chen,Hongyu Zhang,Stephanie H. Kim,Jing Cui,Ruidong Li,Wenwen Zhang,Yuhan Kong,Jiye Zhang,Wei Shui,Joseph D. Lamplot,Mary Rose Rogers,Chen Zhao,Ning Wang,Prashant Rajan,Justin Tomal,Joseph Statz,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He +22 more
TL;DR: The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential and indicates it requires cautious approach due to risks of tumorigenesis.
Journal ArticleDOI
BMP2 induces chondrogenic differentiation, osteogenic differentiation and endochondral ossification in stem cells
Nian Zhou,Qi Li,Xin Lin,Ning Hu,Junyi Liao,Liangbo Lin,Chen Zhao,Zhenming Hu,Xi Liang,Wei Xu,Hong Chen,Wei Huang +11 more
TL;DR: The data reveal that BMP2 can spontaneously induce chondrogenic differentiation, osteogenic differentiation and endochondral bone formation within the same system and has to be properly regulated for cartilage tissue engineering in order to retain the cartilage phenotype.
Journal ArticleDOI
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells
Ning Hu,Dianming Jiang,Enyi Huang,Enyi Huang,Xing Liu,Xing Liu,Ruidong Li,Ruidong Li,Xi Liang,Xi Liang,Stephanie H. Kim,Xiang Chen,Xiang Chen,Jian-Li Gao,Jian-Li Gao,Hongyu Zhang,Hongyu Zhang,Wenwen Zhang,Wenwen Zhang,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Wei Shui,Wei Shui,Xiaoji Luo,Xiaoji Luo,Bo Liu,Bo Liu,Jing Cui,Jing Cui,Mary Rose Rogers,Jikun Shen,Chen Zhao,Chen Zhao,Ning Wang,Ning Wang,Ningning Wu,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Wei Huang +44 more
TL;DR: These findings should not only expand the understanding of the molecular basis behind BMP9-regulated osteoblastic lineage-specific differentiation, but also provide an opportunity to harness the B MP9-induced synergy between osteogenic and angiogenic signaling pathways in regenerative medicine.