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Ningning Wu
Researcher at University of Chicago
Publications - 22
Citations - 1367
Ningning Wu is an academic researcher from University of Chicago. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 19, co-authored 21 publications receiving 1224 citations. Previous affiliations of Ningning Wu include Chinese Ministry of Education & Chongqing Medical University.
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Journal ArticleDOI
Wnt signaling in bone formation and its therapeutic potential for bone diseases
Jeong Hwan Kim,Xing Liu,Jinhua Wang,Xiang Chen,Hongyu Zhang,Stephanie H. Kim,Jing Cui,Ruidong Li,Wenwen Zhang,Yuhan Kong,Jiye Zhang,Wei Shui,Joseph D. Lamplot,Mary Rose Rogers,Chen Zhao,Ning Wang,Prashant Rajan,Justin Tomal,Joseph Statz,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He +22 more
TL;DR: The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential and indicates it requires cautious approach due to risks of tumorigenesis.
Journal ArticleDOI
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells
Ning Hu,Dianming Jiang,Enyi Huang,Enyi Huang,Xing Liu,Xing Liu,Ruidong Li,Ruidong Li,Xi Liang,Xi Liang,Stephanie H. Kim,Xiang Chen,Xiang Chen,Jian-Li Gao,Jian-Li Gao,Hongyu Zhang,Hongyu Zhang,Wenwen Zhang,Wenwen Zhang,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Wei Shui,Wei Shui,Xiaoji Luo,Xiaoji Luo,Bo Liu,Bo Liu,Jing Cui,Jing Cui,Mary Rose Rogers,Jikun Shen,Chen Zhao,Chen Zhao,Ning Wang,Ning Wang,Ningning Wu,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Wei Huang +44 more
TL;DR: These findings should not only expand the understanding of the molecular basis behind BMP9-regulated osteoblastic lineage-specific differentiation, but also provide an opportunity to harness the B MP9-induced synergy between osteogenic and angiogenic signaling pathways in regenerative medicine.
Journal ArticleDOI
Crosstalk between Wnt/β-Catenin and Estrogen Receptor Signaling Synergistically Promotes Osteogenic Differentiation of Mesenchymal Progenitor Cells
Yanhong Gao,Yanhong Gao,Enyi Huang,Enyi Huang,Hongmei Zhang,Hongmei Zhang,Jinhua Wang,Jinhua Wang,Ningning Wu,Ningning Wu,Xian Chen,Xian Chen,Ning Wang,Ning Wang,Sheng Wen,Sheng Wen,Guoxin Nan,Guoxin Nan,Fang Deng,Fang Deng,Zhan Liao,Zhan Liao,Di Wu,Bosi Zhang,Junhui Zhang,Junhui Zhang,Rex C. Haydon,Hue H. Luu,Lewis L. Shi,Tong-Chuan He,Tong-Chuan He +30 more
TL;DR: It is found that the activation of estrogen receptor (ER) signaling by estradiol (E2) or exogenously expressed ERα in MPCs synergistically enhances Wnt3A-induced early and late osteogenic markers, as well as matrix mineralization.
Journal ArticleDOI
Noggin resistance contributes to the potent osteogenic capability of BMP9 in mesenchymal stem cells.
Yi Wang,Yi Wang,Si-Qi Hong,Ming Li,Ming Li,Jiye Zhang,Jiye Zhang,Yang Bi,Yang Bi,Yun He,Yun He,Xing Liu,Xing Liu,Guoxin Nan,Guoxin Nan,Yuxi Su,Yuxi Su,Gao-Hui Zhu,Gao-Hui Zhu,Ruidong Li,Ruidong Li,Wenwen Zhang,Wenwen Zhang,Jinhua Wang,Jinhua Wang,Hongyu Zhang,Hongyu Zhang,Yuhan Kong,Yuhan Kong,Wei Shui,Wei Shui,Ningning Wu,Ningning Wu,Yunfeng He,Yunfeng He,Xian Chen,Xian Chen,Hue H. Luu,Rex C. Haydon,Lewis L. Shi,Tong-Chuan He,Tong-Chuan He,Jiaqiang Qin,Jiaqiang Qin +43 more
TL;DR: The results strongly suggest that BMP9 may effectively overcome noggin inhibition, which should at least in part contribute to B MP9's potent osteogenic capability in MSCs.
Journal ArticleDOI
Adenovirus-mediated gene transfer in mesenchymal stem cells can be significantly enhanced by the cationic polymer polybrene.
Chen Zhao,Ningning Wu,Fang Deng,Hongmei Zhang,Ning Wang,Wenwen Zhang,Xian Chen,Sheng Wen,Junhui Zhang,Liangjun Yin,Zhan Liao,Zhonglin Zhang,Qian Zhang,Zhengjian Yan,Wei Liu,Di Wu,Jixing Ye,Youlin Deng,Guolin Zhou,Hue H. Luu,Rex C. Haydon,Weike Si,Tong-Chuan He +22 more
TL;DR: Results demonstrate that Polybrene should be routinely used as a safe, effective and inexpensive augmenting agent for adenovirus-mediated gene transfer in MSCs, as well as other types of mammalian cells.