W
Wenwen Zhang
Researcher at University of Chicago
Publications - 40
Citations - 3148
Wenwen Zhang is an academic researcher from University of Chicago. The author has contributed to research in topics: Mesenchymal stem cell & Cellular differentiation. The author has an hindex of 27, co-authored 38 publications receiving 2297 citations. Previous affiliations of Wenwen Zhang include Chinese Ministry of Education & Chongqing Medical University.
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Journal ArticleDOI
Notch Signaling Augments BMP9-Induced Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells (MSCs).
Junyi Liao,Qiang Wei,Yulong Zou,Jiaming Fan,Dongzhe Song,Jing Cui,Wenwen Zhang,Yunxiao Zhu,Chao Ma,Xue Hu,Xiangyang Qu,Liqun Chen,Xinyi Yu,Zhicai Zhang,Claire Q.F. Wang,Chen Zhao,Zongyue Zeng,Ruyi Zhang,Shujuan Yan,Tingting Wu,Xingye Wu,Yi Shu,Jiayan Lei,Yasha Li,Hue H. Luu,Michael J. Lee,Russell R. Reid,Guillermo A. Ameer,Jennifer Moriatis Wolf,Tong-Chuan He,Wei Huang +30 more
TL;DR: It’s conceivable that simultaneous activation of the BMP9 and Notch pathways should efficiently couple osteogenesis and angiogenesis of MSCs for successful bone tissue engineering.
Journal ArticleDOI
Adenovirus-mediated gene delivery: Potential applications for gene and cell-based therapies in the new era of personalized medicine
Cody S. Lee,Elliot S. Bishop,Ruyi Zhang,Ruyi Zhang,Xinyi Yu,Xinyi Yu,Evan M. Farina,Shujuan Yan,Shujuan Yan,Chen Zhao,Chen Zhao,Zongyue Zeng,Zongyue Zeng,Yi Shu,Yi Shu,Xingye Wu,Xingye Wu,Jiayan Lei,Jiayan Lei,Yasha Li,Yasha Li,Wenwen Zhang,Wenwen Zhang,Chao Yang,Chao Yang,Ke Wu,Ke Wu,Ying Wu,Ying Wu,Sherwin S. W. Ho,Aravind Athiviraham,Michael J. Lee,Jennifer Moriatis Wolf,Russell R. Reid,Tong-Chuan He +34 more
TL;DR: It is expected that the continued improvements in adenoviral vectors should provide great opportunities for cell and gene therapies to live up to its enormous potential in personalized medicine.
Journal ArticleDOI
Wnt signaling in bone formation and its therapeutic potential for bone diseases
Jeong Hwan Kim,Xing Liu,Jinhua Wang,Xiang Chen,Hongyu Zhang,Stephanie H. Kim,Jing Cui,Ruidong Li,Wenwen Zhang,Yuhan Kong,Jiye Zhang,Wei Shui,Joseph D. Lamplot,Mary Rose Rogers,Chen Zhao,Ning Wang,Prashant Rajan,Justin Tomal,Joseph Statz,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He +22 more
TL;DR: The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential and indicates it requires cautious approach due to risks of tumorigenesis.
Journal ArticleDOI
BMP signaling in mesenchymal stem cell differentiation and bone formation.
Maureen Beederman,Joseph D. Lamplot,Guoxin Nan,Jinhua Wang,Xing Liu,Liangjun Yin,Ruidong Li,Wei Shui,Hongyu Zhang,Stephanie H. Kim,Wenwen Zhang,Jiye Zhang,Yuhan Kong,Sahitya K. Denduluri,Mary Rose Rogers,Abdullah Pratt,Rex C. Haydon,Hue H. Luu,Jovito Angeles,Lewis L. Shi,Tong-Chuan He +20 more
TL;DR: Current knowledge of BMP-mediated osteogenesis is summarized, with a focus on BMP9, by presenting recently completed work which may help to further elucidate these pathways.
Journal ArticleDOI
BMP9 signaling in stem cell differentiation and osteogenesis.
Joseph D. Lamplot,Jiaqiang Qin,Guoxin Nan,Jinhua Wang,Xing Liu,Liangjun Yin,Justin Tomal,Ruidong Li,Wei Shui,Hongyu Zhang,Stephanie H. Kim,Wenwen Zhang,Jiye Zhang,Yuhan Kong,Sahitya K. Denduluri,Mary Rose Rogers,Abdullah Pratt,Rex C. Haydon,Hue H. Luu,Jovito Angeles,Lewis L. Shi,Tong-Chuan He +21 more
TL;DR: In this paper, the authors summarize the current knowledge of BMP9-mediated osteogenesis by presenting recently completed work which may help us to further elucidate these pathways, and they conclude that BMP-9 is known to be a potent osteogenic factor, it also influences several other pathways including cancer development, angiogenesis and myogenesis.