X
Xiang Chen
Researcher at University of Chicago
Publications - 13
Citations - 1001
Xiang Chen is an academic researcher from University of Chicago. The author has contributed to research in topics: Mesenchymal stem cell & Cellular differentiation. The author has an hindex of 12, co-authored 12 publications receiving 880 citations. Previous affiliations of Xiang Chen include Fourth Military Medical University.
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Journal ArticleDOI
Wnt signaling in bone formation and its therapeutic potential for bone diseases
Jeong Hwan Kim,Xing Liu,Jinhua Wang,Xiang Chen,Hongyu Zhang,Stephanie H. Kim,Jing Cui,Ruidong Li,Wenwen Zhang,Yuhan Kong,Jiye Zhang,Wei Shui,Joseph D. Lamplot,Mary Rose Rogers,Chen Zhao,Ning Wang,Prashant Rajan,Justin Tomal,Joseph Statz,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He +22 more
TL;DR: The present review discusses the role of the Wnt signaling pathway in osteogenesis and examines its targeted therapeutic potential and indicates it requires cautious approach due to risks of tumorigenesis.
Journal ArticleDOI
Growth hormone synergizes with BMP9 in osteogenic differentiation by activating the JAK/STAT/IGF1 pathway in murine multilineage cells.
Enyi Huang,Gao-Hui Zhu,Gao-Hui Zhu,Wei Jiang,Ke Yang,Ke Yang,Yanhong Gao,Yanhong Gao,Qing Luo,Qing Luo,Jian-Li Gao,Jian-Li Gao,Stephanie H. Kim,Xing Liu,Xing Liu,Mi Li,Mi Li,Qiong Shi,Qiong Shi,Ning Hu,Ning Hu,Linyuan Wang,Hong Liu,Hong Liu,Jing Cui,Jing Cui,Wenwen Zhang,Wenwen Zhang,Ruidong Li,Ruidong Li,Xiang Chen,Xiang Chen,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Jikun Shen,Yang Bi,Yang Bi,Joseph Statz,Bai-Cheng He,Bai-Cheng He,Jinyong Luo,Jinyong Luo,Huicong Wang,Feng Xiong,Hue H. Luu,Rex C. Haydon,Li Yang,Tong-Chuan He,Tong-Chuan He +52 more
TL;DR: Bone morphogenic protein 9 (BMP9) is identified as one of the most osteogenic BMPs in MMCs by regulating a distinct set of downstream mediators and it is conceivable that the BMP9‐GH‐IGF axis may be exploited as an innovative strategy to enhance osteogenesis in regenerative medicine.
Journal ArticleDOI
BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells
Ning Hu,Dianming Jiang,Enyi Huang,Enyi Huang,Xing Liu,Xing Liu,Ruidong Li,Ruidong Li,Xi Liang,Xi Liang,Stephanie H. Kim,Xiang Chen,Xiang Chen,Jian-Li Gao,Jian-Li Gao,Hongyu Zhang,Hongyu Zhang,Wenwen Zhang,Wenwen Zhang,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Wei Shui,Wei Shui,Xiaoji Luo,Xiaoji Luo,Bo Liu,Bo Liu,Jing Cui,Jing Cui,Mary Rose Rogers,Jikun Shen,Chen Zhao,Chen Zhao,Ning Wang,Ning Wang,Ningning Wu,Ningning Wu,Hue H. Luu,Rex C. Haydon,Tong-Chuan He,Wei Huang +44 more
TL;DR: These findings should not only expand the understanding of the molecular basis behind BMP9-regulated osteoblastic lineage-specific differentiation, but also provide an opportunity to harness the B MP9-induced synergy between osteogenic and angiogenic signaling pathways in regenerative medicine.
Journal ArticleDOI
Conditionally immortalized mouse embryonic fibroblasts retain proliferative activity without compromising multipotent differentiation potential.
Enyi Huang,Enyi Huang,Yang Bi,Yang Bi,Wei Jiang,Xiaoji Luo,Xiaoji Luo,Ke Yang,Ke Yang,Jian-Li Gao,Jian-Li Gao,Yanhong Gao,Yanhong Gao,Qing Luo,Qing Luo,Qiong Shi,Qiong Shi,Stephanie H. Kim,Xing Liu,Xing Liu,Mi Li,Mi Li,Ning Hu,Ning Hu,Hong Liu,Hong Liu,Jing Cui,Jing Cui,Wenwen Zhang,Wenwen Zhang,Ruidong Li,Ruidong Li,Xiang Chen,Xiang Chen,Jikun Shen,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Jinyong Luo,Jinyong Luo,Bai-Cheng He,Bai-Cheng He,Huicong Wang,Russell R. Reid,Hue H. Luu,Rex C. Haydon,Li Yang,Tong-Chuan He,Tong-Chuan He +51 more
TL;DR: The results suggest that the reversible immortalization strategy using SV40 large T antigen may be an efficient and safe approach to establishing long-term cell culture of primary mesenchymal progenitors for basic and translational research, as well as for potential clinical applications.
Journal ArticleDOI
Cross-talk between EGF and BMP9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells
Xing Liu,Jiaqiang Qin,Jiaqiang Qin,Qing Luo,Qing Luo,Yang Bi,Yang Bi,Gao-Hui Zhu,Gao-Hui Zhu,Wei Jiang,Stephanie H. Kim,Mi Li,Mi Li,Yuxi Su,Yuxi Su,Guoxin Nan,Guoxin Nan,Jing Cui,Jing Cui,Wenwen Zhang,Wenwen Zhang,Ruidong Li,Ruidong Li,Xiang Chen,Xiang Chen,Yuhan Kong,Yuhan Kong,Jiye Zhang,Jiye Zhang,Jinhua Wang,Jinhua Wang,Mary Rose Rogers,Hongyu Zhang,Hongyu Zhang,Wei Shui,Wei Shui,Chen Zhao,Chen Zhao,Ning Wang,Ning Wang,Xi Liang,Xi Liang,Ningning Wu,Ningning Wu,Yunfeng He,Yunfeng He,Hue H. Luu,Rex C. Haydon,Lewis L. Shi,Tingyu Li,Tong-Chuan He,Tong-Chuan He,Ming Li +52 more
TL;DR: It is found that EGF potentiates BMP9‐induced early and late osteogenic markers of MSCs in vitro, which can be effectively blunted by EGFR inhibitors Gefitinib and Erlotinib or receptor tyrosine kinase inhibitors AG‐1478 and AG‐494 in a dose‐ and time‐dependent manner.