Aviva M. Tolkovsky

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.

TL;DR: It is shown that puckered mutations result in the hyperactivation of DJNK, and that overexpression of puc mimics basket mutant phenotypes and that during dorsal closure, JNK signaling has a dual role: to activate an effector, encoded by decapentaplegic, and an element of negative feedback regulation encoded by pucered.

TL;DR: It is proposed that the same apoptotic signals that cause mitochondrial dysfunction also activate autophagy, a mechanism whereby cells digest themselves from within and so may be used in lieu of apoptosis to execute cell death.

TL;DR: These conditions raise the possibility that autophagy can have either deleterious or protective effects depending on the specific situation and stage in the pathological process, including the Lurcher mouse and a range of chronic neurodegenerative conditions.