scispace - formally typeset
C

Clark W. Distelhorst

Researcher at Case Western Reserve University

Publications -  77
Citations -  12697

Clark W. Distelhorst is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Apoptosis & Endoplasmic reticulum. The author has an hindex of 41, co-authored 75 publications receiving 11509 citations. Previous affiliations of Clark W. Distelhorst include University Hospitals of Cleveland.

Papers
More filters
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, +235 more
- 16 Feb 2008 - 
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Journal ArticleDOI

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

Minh Lam, +5 more
- 05 Jul 1994 - 
TL;DR: It is suggested that BCL-2 either directly or indirectly regulates the flux of Ca2+ across the ER membrane, thereby abrogating Ca2- signaling of apoptosis.
Journal ArticleDOI

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis.

Yiping Rong, +1 more
- 13 Feb 2008 - 
TL;DR: Findings indicate that Bcl-2 interacts with inositol 1,4,5-trisphosphate (IP3) receptor Ca2+ channels on the ER, regulating their opening in response to IP3- and thus inhibiting IP2+ signals that induce apoptosis while enhancing Ca2 + signals that support cell survival.
Journal ArticleDOI

Apoptosis--the Calcium Connection

Nicolas Demaurex, +1 more
- 04 Apr 2003 - 
TL;DR: New work that shows how calcium ions flowing between the endoplasmic reticulum (ER) and mitochondria regulate programmed cell death, highlighting the ER as a new gateway to apoptosis.