J
John L. Cleveland
Researcher at Scripps Research Institute
Publications - 257
Citations - 29431
John L. Cleveland is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Apoptosis & Gene. The author has an hindex of 83, co-authored 241 publications receiving 27222 citations. Previous affiliations of John L. Cleveland include Ben-Gurion University of the Negev & W. Alton Jones Cell Science Center.
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Journal ArticleDOI
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Daniel J. Klionsky,Hagai Abeliovich,Patrizia Agostinis,Devendra K. Agrawal,Gjumrakch Aliev,David S. Askew,Misuzu Baba,Eric H. Baehrecke,Ben A. Bahr,Andrea Ballabio,Bruce A. Bamber,Diane C. Bassham,Ettore Bergamini,Xiaoning Bi,Martine Biard-Piechaczyk,Janice S. Blum,Dale E. Bredesen,Jeffrey L. Brodsky,John H. Brumell,Ulf T. Brunk,Wilfried Bursch,Nadine Camougrand,Eduardo Cebollero,Francesco Cecconi,Yingyu Chen,Lih-Shen Chin,Augustine M.K. Choi,Charleen T. Chu,Jongkyeong Chung,Peter G.H. Clarke,Robert S. B. Clark,Steven Clarke,Corinne Clavé,John L. Cleveland,Patrice Codogno,María Isabel Colombo,Ana Coto-Montes,James M. Cregg,Ana Maria Cuervo,Jayanta Debnath,Francesca Demarchi,Patrick B. Dennis,Phillip A. Dennis,Vojo Deretic,Rodney J. Devenish,Federica Di Sano,J. Fred Dice,Marian DiFiglia,Savithramma P. Dinesh-Kumar,Clark W. Distelhorst,Mojgan Djavaheri-Mergny,Frank C. Dorsey,Wulf Dröge,Michel Dron,William A. Dunn,Michael Duszenko,N. Tony Eissa,Zvulun Elazar,Audrey Esclatine,Eeva-Liisa Eskelinen,László Fésüs,Kim D. Finley,José M. Fuentes,Juan Fueyo,Kozo Fujisaki,Brigitte Galliot,Fen-Biao Gao,David A. Gewirtz,Spencer B. Gibson,Antje Gohla,Alfred L. Goldberg,Ramon Gonzalez,Cristina González-Estévez,Sharon M. Gorski,Roberta A. Gottlieb,Dieter Häussinger,You-Wen He,Kim A. Heidenreich,Joseph A. Hill,Maria Høyer-Hansen,Xun Hu,Wei-Pang Huang,Akiko Iwasaki,Marja Jäättelä,William T. Jackson,Xuejun Jiang,Shengkan Jin,Terje Johansen,Jae U. Jung,Motoni Kadowaki,Chanhee Kang,Ameeta Kelekar,David Kessel,Jan A.K.W. Kiel,Pyo Kim Hong,Adi Kimchi,Timothy J. Kinsella,Kirill Kiselyov,Katsuhiko Kitamoto,Erwin Knecht,Masaaki Komatsu,Eiki Kominami,Seiji Kondo,Attila L. Kovács,Guido Kroemer,Chia Yi Kuan,Rakesh Kumar,Mondira Kundu,Jacques Landry,Marianne M. Laporte,Weidong Le,Huan Yao Lei,Michael J. Lenardo,Beth Levine,Andrew P. Lieberman,Kah-Leong Lim,Fu-Cheng Lin,Willisa Liou,Leroy F. Liu,Gabriel Lopez-Berestein,Carlos López-Otín,Bo Lu,Kay F. Macleod,Walter Malorni,Wim Martinet,Ken Matsuoka,Josef Mautner,Alfred J. Meijer,Alicia Meléndez,Paul A.M. Michels,Giovanni Miotto,Wilhelm P. Mistiaen,Noboru Mizushima,Baharia Mograbi,Iryna Monastyrska,Michael Moore,Paula I. Moreira,Yuji Moriyasu,Tomasz Motyl,Christian Münz,Leon Murphy,Naweed I. Naqvi,Thomas P. Neufeld,Ichizo Nishino,Ralph A. Nixon,Takeshi Noda,Bernd Nürnberg,Michinaga Ogawa,Nancy L. Oleinick,Laura J. Olsen,Bulent Ozpolat,Shoshana Paglin,Glen E. Palmer,Issidora S. Papassideri,Miles Parkes,David H. Perlmutter,George Perry,Mauro Piacentini,Ronit Pinkas-Kramarski,Mark Prescott,Tassula Proikas-Cezanne,Nina Raben,Abdelhaq Rami,Fulvio Reggiori,Bärbel Rohrer,David C. Rubinsztein,Kevin M. Ryan,Junichi Sadoshima,Hiroshi Sakagami,Yasuyoshi Sakai,Marco Sandri,Chihiro Sasakawa,Miklós Sass,Claudio Schneider,Per Ottar Seglen,Oleksandr Seleverstov,Jeffrey Settleman,John J. Shacka,Irving M. Shapiro,Andrei A. Sibirny,Elaine C.M. Silva-Zacarin,Hans-Uwe Simon,Crisfiano Simone,Anne Simonsen,Mark A. Smith,Katharina Spanel-Borowski,Vickram Srinivas,Meredith A. Steeves,Harald Stenmark,Per E. Stromhaug,Carlos S. Subauste,Seiichiro Sugimoto,David Sulzer,Toshihiko Suzuki,Michele S. Swanson,Ira Tabas,Fumihiko Takeshita,Nicholas J. Talbot,Zsolt Tallóczy,Keiji Tanaka,Kozo Tanaka,Isei Tanida,Graham S. Taylor,J. Paul Taylor,Alexei Terman,Gianluca Tettamanti,Craig B. Thompson,Michael Thumm,Aviva M. Tolkovsky,Sharon A. Tooze,Ray Truant,Lesya V. Tumanovska,Yasuo Uchiyama,Takashi Ueno,Néstor L. Uzcátegui,Ida J. van der Klei,Eva C. Vaquero,Tibor Vellai,Michael W. Vogel,Hong Gang Wang,Paul Webster,John W. Wiley,Zhijun Xi,Gutian Xiao,Joachim Yahalom,Jin Ming Yang,George S. Yap,Xiao Ming Yin,Tamotsu Yoshimori,Li Yu,Zhenyu Yue,Michisuke Yuzaki,Olga Zabirnyk,Xiaoxiang Zheng,Xiongwei Zhu,Russell L. Deter +235 more
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Journal ArticleDOI
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
Frederique Zindy,Christine M. Eischen,David H. Randle,Takehiko Kamijo,John L. Cleveland,Charles J. Sherr,Martine F. Roussel +6 more
TL;DR: MEFs that survive myc overexpression sustain p53 mutation or ARF loss during the process of establishment and become immortal, and ARF regulates a p53-dependent checkpoint that safeguards cells against hyperproliferative, oncogenic signals.
Journal ArticleDOI
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Miguel A. Sanjuan,Christopher P. Dillon,Stephen W.G. Tait,Simon Moshiach,Frank C. Dorsey,Samuel Connell,Masaaki Komatsu,Keiji Tanaka,John L. Cleveland,Sebo Withoff,Douglas R. Green +10 more
TL;DR: It is shown that a particle that engages TLRs on a murine macrophage while it is phagocytosed triggers the autophagosome marker LC3 to be rapidly recruited to the phagosome in a manner that depends on theAutophagy pathway proteins ATG5 and ATG7; this process is preceded by recruitment of beclin 1 and phosphoinositide-3-OH kinase activity.
Journal Article
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
TL;DR: The premature induction of apoptosis in cells harboring a deregulated c-myc gene suggests that apoptosis may be an important mechanism in the elimination of hematopoietic cells Harboring mutations, such as constitutive c- myc expression, which imbalance normal cell cycle regulatory controls.
Journal ArticleDOI
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
John R. Jeffers,Evan Parganas,Evan Parganas,Youngsoo Lee,Chunying Yang,Jinling Wang,Jennifer Brennan,Kirsteen H. Maclean,Jia-wen Han,Thomas Chittenden,James N. Ihle,James N. Ihle,Peter J. McKinnon,John L. Cleveland,Gerard P. Zambetti +14 more
TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.