Xun Hu

TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.

TL;DR: It is shown that shikonin-induced necroptosis can be reverted to apoptosis in the presence of necrostatin-1 (Nec-1), a specific ne croptosis inhibitor and that the death mode switch is at least partially due to the conversion from mitochondrial inner membrane permeability to mitochondrial outer membrane permeable, which is associated with Bax translocation.

TL;DR: It is shown that the naturally-occurring shikonin analogues could bypass drug resistance mediated by not only P-gp, Bcl-2, and BCl-xL, but also two additional important drug-resistant factors MRP1 and BCRP1, by induction of necroptosis.

TL;DR: This study randomly chose 4 cancer cell lines and primary colon or rectal cancer cells from 4 patients to test the hypothesis of a dose-response relationship between cellular ROS level and cytotoxicity and obtained paradoxical results.

TL;DR: It is shown that Honokiol down-regulated the expression of P-glycoprotein at mRNA and protein levels in MCF-7/ADR, a human breast MDR cancer cell line, revealing a novel function of honokiol as an anti-cancer agent.