Meredith A. Steeves

TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.

TL;DR: A model in which ATM plays direct roles in modulating mitochondrial homeostasis is supported and it is suggested that mitochondrial dysfunction and associated increases in mitochondrial reactive oxygen species contribute to the cancer-prone phenotype observed in organisms lacking ATM.

TL;DR: Findings establish a direct pathway that integrates Ulk1- and Atg13-directed mitophagy with the stress response coordinated by Hsp90 and Cdc37.

TL;DR: ODC in macrophages tempers antimicrobial, M1 macrophage responses during bacterial infections through histone modifications and altered euchromatin formation, leading to the persistence and pathogenesis of these organisms.

TL;DR: There is a selection for TTP loss in malignancy; thus, TTP functions as a tumor suppressor and Myc/TTP-directed control of select cancer-associated ARED genes is disabled during lymphomagenesis.