Chanhee Kang

TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: This work mapped the critical region for senescence-induced activity and identified the transcriptional regulator responsible for this regulation, GATA4, previously known as a regulator of embryonic development, which affects senescent cells and their microenvironment and suggests the existence of an independent senescENCE regulatory network that controls the SASP.

TL;DR: It is demonstrated that autophagy can have either prosurvival or prodeath functions in an organism, depending on its level of activation, as well as that in gpb-2 mutants, in which muscarinic signaling cannot be down-regulated, starvation induces excessive Autophagy in pharyngeal muscles.

TL;DR: This recent study revealed distinctive roles of selective Autophagy and general autophagy in the regulation of senescence, at least in part resolving apparently contradictory reports regarding the relationship between these 2 important homeostatic stress responses.