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Néstor L. Uzcátegui

Researcher at Central University of Venezuela

Publications -  37
Citations -  8483

Néstor L. Uzcátegui is an academic researcher from Central University of Venezuela. The author has contributed to research in topics: Trypanosoma brucei & Aquaglyceroporins. The author has an hindex of 17, co-authored 37 publications receiving 7908 citations. Previous affiliations of Néstor L. Uzcátegui include University of Tübingen & Wayne State University.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Daniel J. Klionsky, +235 more
- 16 Feb 2008 - 
TL;DR: A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
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Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis.

TL;DR: Leishmania LmAQP1 has multiple physiological roles, being involved in solute transport, volume regulation and osmotaxis, and this is the first report of an aquaglyceroporin being localized to the flagellum of any microbe.
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Prostaglandin D2 induces programmed cell death in Trypanosoma brucei bloodstream form.

TL;DR: In bloodstream form trypanosomes PGD2 induces an apoptosis-like programmed cell death, which includes maintenance of plasma membrane integrity, phosphatidylserine exposure, loss of mitochondrial membrane potential, nuclear chromatin condensation and DNA degradation, indicating that the process is caspase-independent.
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Cloning, heterologous expression, and characterization of three aquaglyceroporins from Trypanosoma brucei.

TL;DR: TbAQPs represent mainly water/glycerol/dihydroxyacetone channels involved in osmoregulation and glycerol metabolism in T. brucei, and may be pivotal for the survival of the parasite survival under non-aerobic or osmotic stress conditions.