Weidong Han

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: Understanding the novel function of autophagy may allow us to develop a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in the treatment of cancer patients.

TL;DR: New insights are provided into p38 and JNK MAPK pathways function in the control of the balance of autophagy and apoptosis in response to genotoxic stress that will hopefully provide prospective strategies for cancer therapy.

TL;DR: Shikonin, a naturally occurring naphthoquinone, induced a cell death in MCF-7 and HEK293 distinct from apoptosis and characterized with (a) a morphology of necrotic cell death, (b) loss of plasma membrane integrity, loss of mitochondrial membrane potentials, activation of autophagy, but not a contributing factor; (e) elevation of reactive oxygen species with no critical roles contributing to cell death; and (f) the cell death was prevented by a small molecule, necrostatin-1, that specifically