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Miguel A. Sanjuan

Researcher at MedImmune

Publications -  56
Citations -  9231

Miguel A. Sanjuan is an academic researcher from MedImmune. The author has contributed to research in topics: Immune system & Autoimmunity. The author has an hindex of 28, co-authored 45 publications receiving 8279 citations. Previous affiliations of Miguel A. Sanjuan include Spanish National Research Council & St. Jude Children's Research Hospital.

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Miguel A. Sanjuan, +10 more
- 20 Dec 2007 - 
TL;DR: It is shown that a particle that engages TLRs on a murine macrophage while it is phagocytosed triggers the autophagosome marker LC3 to be rapidly recruited to the phagosome in a manner that depends on theAutophagy pathway proteins ATG5 and ATG7; this process is preceded by recruitment of beclin 1 and phosphoinositide-3-OH kinase activity.
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Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

Jill Henault, +13 more
- 14 Dec 2012 - 
TL;DR: These findings unveil a new role for nonconventional autophagy in inflammation and provide one mechanism by which anti-DNA autoantibodies, such as those found in several autoimmune disorders, bypass the controls that normally restrict the apportionment of pathogenic DNA and TLR9 to the interferon signaling compartment.
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Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

Sarah L. Rowland, +9 more
- 22 Sep 2014 - 
TL;DR: Transient, genetic elimination of a specialized group of cells called plasmacytoid dendritic cells (pDCs) reverses many features of lupus in mice.
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T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.

Roselynn Rodriguez-Manzanet, +8 more
- 11 May 2010 - 
TL;DR: It is shown that TIM- 4 is critical for the clearance of apoptotic bodies in vivo, and that lack of TIM-4 results in aberrant persistence of apoptosis leading to dysregulated lymphocyte activation and signs of systemic autoimmunity.